For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio , he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
The longevity and mitochondrial function benefits of C60, particularly ESS-60, are examined, with Chris Burres, the original manufacturer of the molecule, as the guest. Discussion points include the molecule's unique electrical properties, its potential for life extension based on rat studies showing a 90% increase in ...
Gabrielle Lyon, DO, discusses muscle-centric medicine, emphasizing the importance of muscle mass for overall health, longevity, and brain function. Lyon highlights intermuscular adipose tissue (IMAT) as a more relevant biomarker than body fat percentage, noting its impact on insulin resistance and metabolic dysfunction...
Dave Asprey discusses how to activate the body's natural GLP-1 system as an alternative to drugs like Ozempic for weight loss. He argues that hunger is a hormonal issue, not a math problem of calories in versus calories out, and that Ozempic overrides rather than repairs the natural appetite system. Asprey suggests str...
The discussion centers on optimizing brain health by targeting mitochondrial function and the brain's immune system. Neurologist Dr. David Perlmutter joins the conversation to discuss how microglial cells, the brain's immune cells, can shift from supportive (M2) to destructive (M1) based on metabolic factors. They expl...
In this episode of The Human Upgrade, Dave Asprey delves into the topic of oxalates, naturally occurring compounds found in plants, and their impact on health. He discusses how oxalates can bind to minerals, form razor-sharp crystals, and accumulate in the body over time, leading to inflammation, pain, and various heal...
In this monologue podcast, Dave Asprey discusses the importance of proper fasting for weight loss and overall health, highlighting common mistakes that lead to muscle loss and metabolic slowdown. He explains how fasting incorrectly can make the body better at storing fat and accelerate aging. Asprey emphasizes the need...
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