27 Jan 2026
1h 2m

Your Butt is a Longevity Organ (Here’s how to train it!) | Gabrielle Lyon : 1405

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The Human Upgrade: Biohacking for Longevity & Performance

Gabrielle Lyon, DO, discusses muscle-centric medicine, emphasizing the importance of muscle mass for overall health, longevity, and brain function. Lyon highlights intermuscular adipose tissue (IMAT) as a more relevant biomarker than body fat percentage, noting its impact on insulin resistance and metabolic dysfunction. She advocates for strength training at any age, even for those with connective tissue disorders, recommending a "crawl, walk, run" approach and blood flow restriction. The conversation explores the connection between physical strength and mental resilience, with Lyon sharing practical tips for building emotional regulation and discernment. She also addresses the impact of GLP-1s on muscle mass and the importance of adequate protein intake for maintaining muscle health.

Outlines

Part 1: Biomarkers, Muscle, and Longevity

Part 2: Women's Health, Hormones, and Strength

Part 3: Training Principles and Muscle Span

Part 4: Mindset, Friction, and Emotional Regulation

Part 5: Mitochondrial Function and Brain Health

Part 6: Advanced Biomarkers and Metabolic Challenges

Part 7: Protein Optimization and Resilience

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