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Dave Asprey · Health

The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio , he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

Episodes

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WW3 Doomscrolling, 5 Minute Sleep Hack, Diet Wars, Dopamine Supplements : 1427

06 Mar 2026
11m
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Your Brain Is 0.5% Plastic (Here’s How to Flush It) : 1426

05 Mar 2026
56m
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Why Are Hackers Microdosing “Sex Drugs” Now? : 1425

03 Mar 2026
53m
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A-List Celebrities' Anti-Aging Hack to Look 30 At 50 (Drug-free) : 1424

01 Mar 2026
14m
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Mexican Cartel Biohacking, Google Anti-Aging Breakthrough, Measles Is Back, Age Reversal In 2026 : 1423

27 Feb 2026
9m
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The Secret to Staying DANGEROUS After 50 : 1422

26 Feb 2026
1h 0m
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This episode of The Human Upgrade explores the world of peptides, focusing on their applications in longevity, cognitive enhancement, and overall health. Dave Asprey interviews Josh Felber and Jay Campbell, experts in the peptide field, to discuss the basics of peptides, including delivery methods like injectable pens ...

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The Home Laser That Reverses Skin Age By 20 Years : 1421

24 Feb 2026
57m
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I Tested The Most Dangerous Viral Brain Hack : 1420

22 Feb 2026
11m
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Plastic in Your Testicles, AI Sleep Scans, The 29% Weight Loss Drug : 1419

20 Feb 2026
11m
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Change Your Morning, Change Your Life – Hal Elrod : 1418

19 Feb 2026
1h 12m
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Dave Asprey interviews Hal Elrod, author of "The Miracle Morning," about his updated book, personal resilience, and morning routines. Elrod recounts surviving a near-fatal car accident and later battling cancer, emphasizing the importance of taking responsibility for one's health. They discuss the Miracle Morning's SAV...

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The Secret to Looking Younger is in Mushrooms (And Chocolate?) : 1417

17 Feb 2026
1h 6m
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Low Testosterone Starts In Your Eyes (Avoid This Before Bed) : 1416

15 Feb 2026
14m
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Jet Lag Superdrug, 25% Dementia Drop, Coffee Brain Aging, Kratom Shakeup : 1415

13 Feb 2026
9m
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Turn Off Your WiFi Tonight and See What Happens to Your Sleep : 1414

12 Feb 2026
47m
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The Secret Peptides and Underground Compounds Doctors Won’t Talk About : 1413

10 Feb 2026
59m
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The podcast explores the use of research chemicals, SARMs, and peptides for performance enhancement and overall health, questioning the conventional definitions of "cheating" and "performance-enhancing drugs." Dylan Gemelli, a biohacker, shares his experiences and insights on these substances, alongside host Dave Aspre...

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Why Your Muscles Break Down After 40 (Do This To Reverse It) : 1412

08 Feb 2026
10m
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Biohackers in the Epstein Files, Generic GLP-1s, Continuous Ketone Monitors, and more... : 1411

06 Feb 2026
7m
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Why 18-Year-Olds Wake Up Fresh (And You Don't) : 1410

05 Feb 2026
58m
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The discussion centers on stem cell exhaustion as a primary cause of aging and strategies to combat it. Christian Drapeau, a stem cell scientist and neuroscientist, explains that stem cell decline, rather than exhaustion, is a key factor, with red marrow converting to fatty marrow over time. He suggests that a three-da...

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STOP Intermittent Fasting If You Want to Stay Young : 1409

03 Feb 2026
1h 17m
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The discussion centers on optimizing longevity through diet and lifestyle, challenging conventional wisdom on protein intake and fasting. Valter Longo, gerontology and biological sciences professor, advocates for a longevity diet that includes fasting-mimicking approaches to promote multisystemic regeneration by activa...

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Aging Starts In Your Legs (Here’s The Fix) : 1408

01 Feb 2026
8m
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