03 Feb 2026
1h 17m

STOP Intermittent Fasting If You Want to Stay Young : 1409

Podcast cover

The Human Upgrade: Biohacking for Longevity & Performance

The discussion centers on optimizing longevity through diet and lifestyle, challenging conventional wisdom on protein intake and fasting. Valter Longo, gerontology and biological sciences professor, advocates for a longevity diet that includes fasting-mimicking approaches to promote multisystemic regeneration by activating stem cells and reprogramming factors. He cautions against high protein intake, linking it to increased risks of diabetes and cardiovascular issues, and emphasizes the importance of balancing low protein levels with the need for muscle synthesis. The conversation explores the nuances of amino acid profiles, the timing of protein absorption, and the potential benefits of glycerol during fasting. Longo stresses the significance of personalized approaches, considering factors like age, genetics, and individual health risks, while advocating for equilibrium.

Outlines

Part 1: Longevity Foundations & Pitfalls

Part 2: Metabolic Mechanisms & Muscle Health

Part 3: Hormonal Pathways & Fasting Protocols

Part 4: Personalization, AI, & Nutrition

Part 5: Equilibrium & Future Outlook

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