Dave Asprey · Health

The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio , he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

Episodes

10 Minute Weekly Biohacking Update : 1347

17 Oct 2025

These Plants Turn On 1,100 Healing Genes In 24 Hours (Ancient Biohacks) : 1346

16 Oct 2025

56m

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In this episode of The Human Upgrade, Dave Asprey interviews Alberto Villoldo about his book "Grow a New Brain," exploring the intersection of science and shamanism. Villoldo shares his personal health journey, including overcoming a dead liver and brain parasites, by integrating traditional Amazonian plant knowledge w...

Solo Episode - Nicotine Masterclass (pt. 1) : 1345

14 Oct 2025

27m

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In this episode of The Human Upgrade, Dave Asprey discusses the potential benefits of microdosing nicotine, separate from the dangers of smoking or tobacco use. He details nicotine's history, mechanisms, and potential cognitive and metabolic advantages, including its role in attention, memory, and reducing inflammation...

In this episode of The Human Upgrade, Dave Asprey interviews Dr. Jason Snibbe, an orthopedic surgeon, about joint health and functional movement. Dr. Snibbe emphasizes the importance of core stability, glute strength, and flexibility for preventing joint damage and the need to consider the kinetic chain in movement and...

Remote Work Is Making You FATTER (Do THIS to Stop It) : 1340

05 Oct 2025

14m

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In this episode of the Human Upgrade, Dave Asprey discusses how remote work can negatively impact health by disrupting hormones like testosterone, cortisol, and insulin. He explains that the lack of movement, poor lighting, and constant screen time associated with working from home can lead to weight gain, fatigue, and...

10-Minute Weekly Update : 1339

03 Oct 2025

10m

How Gravity Shapes Your Body, Brain, and Health : 1338

02 Oct 2025

1h 0m

Modafinil Masterclass: Clarity, Drive, and Longevity | Solo Pod : 1337

30 Sep 2025

47m

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In this episode of The Human Upgrade, Dave Asprey delves into the science, benefits, and risks of Modafinil, a prescription drug known for enhancing wakefulness, focus, and cognitive function. Asprey shares his personal experiences with Modafinil, explaining how it helped him overcome cognitive challenges and improve h...