Dave Asprey · Health

The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio , he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

Episodes

In this episode of The Human Upgrade, Dave Asprey interviews Sten Stray, a researcher in metabolic physiology, about blood flow restriction (BFR) training and intermittent hypoxia. They discuss the benefits of altitude acclimation, the physiological responses to hypoxia and hyperoxia, and how intermittent hypoxia can i...

Why Motivation DOESN’T Work | Mental Biohacks : 1361

11 Nov 2025

39m

New Japanese Walking Hack Burns More Fat Than 10,000 Steps : 1360

09 Nov 2025

Biohacking News Weekly Update : 1359

07 Nov 2025

11m

The Strange Science Behind Tylenol and Heartbreak | Daniel Amen : 1358

06 Nov 2025

1h 0m

The New SCIENCE of Energy Healing | Biohacking Updated : 1357

04 Nov 2025

37m

Your Body Has an Anti-Aging Switch (Here’s How to Turn It On) : 1356

02 Nov 2025

21m

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In this monologue podcast, Dave Asprey discusses anti-aging strategies, focusing on the science behind aging and how to reverse it. He debunks the idea that aging is solely determined by genetics or time, highlighting cellular dysfunction, particularly mitochondrial health, as a key factor. Asprey introduces three meth...

What Happens When You Live Inside a Quantum Field? (Anti-Aging Secrets) : 1355

31 Oct 2025

45m

Master Stress in 10 Seconds with THIS Heartbeat Technique : 1354

30 Oct 2025

1h 10m

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Heart rate variability (HRV) and heart-brain coherence are explored as keys to self-regulation, resilience, and enhanced consciousness. Rollin McCraty from the HeartMath Institute explains HRV as the beat-to-beat change in heart rate, reflecting the body's ability to self-regulate and adapt to stress. The discussion co...

Biohacking Cannabis: The DNA Science of Plant Medicine : 1353

28 Oct 2025

43m

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In this episode of The Human Upgrade, Dave Asprey interviews Len May, CEO of EndoDNA, about the role of genetics in health, cannabis use, and responses to pharmaceuticals and psychedelics. Len explains the endocannabinoid system and how genetic testing can help individuals understand their predispositions to adverse ef...

This Legal Focus Powder Beats Any Dopamine Detox : 1352

26 Oct 2025

18m

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In this monologue podcast, Dave Asprey discusses strategies for enhancing brain energy and cognitive function. He begins by promoting the Echoflask, a hydrogen water generator, for its potential health benefits. He then shifts to the primary topic: addressing brain energy crises by focusing on mitochondrial function an...

Biohacking News Weekly Update : 1351

24 Oct 2025

How Biohackers Use Nicotine WITHOUT Getting Addicted : 1350

23 Oct 2025

34m

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In this episode of The Human Upgrade, Dave Asprey delves into the science and practical applications of nicotine as a nootropic and potential longevity drug, distinguishing it from the dangers of smoking. He discusses the mechanisms through which nicotine affects the brain, its potential benefits for focus, memory, and...