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Nick Jikomes · Health

Mind & Matter

Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it. The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today. Not medical advice. At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it. As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet. I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint. My beliefs: Taking ownership of your health starts with taking ownership of your information diet . All knowledge is provisional and we must work hard to prevent ourselves from becoming attached to our favorite ideas & preferred conclusions. Wisdom comes from an iterative, trial-and-error process of learning and unlearning. Letting go of pre-conceived notions can be painful, but pain is information. Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload & historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi: “Γνῶθι σεαυτόν” ( Know thyself ) “Μηδὲν ἄγαν” ( Nothing in excess) “Ἐγγύα πάρα δ Ἄτα” ( Certainty brings insanity)

Episodes

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Psilocybin vs. SSRIs for Depression, Emotional Blunting & How Psychedelics Work | Robin Carhart-Harris | Episode 310

26 Oct 2026
1h 55m
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This Animal Survives 18 Minutes Without Oxygen | Gary Lewin | Episode 309

12 Oct 2026
1h 40m
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Selenium, Thyroid Autoimmunity & Selenoprotein P | Lutz Schomburg | Episode 308

05 Oct 2026
1h 44m
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Effects of Dietary Sugars on Human Health | Kimber Stanhope | Episode 307

15 Sep 2026
1h 52m
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Human Brain Evolution & Development | Christopher Walsh | Episode 306

28 Aug 2026
1h 45m
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Endocannabinoid Biology in Health & Disease | Nephi Stella | Episode 305

20 Aug 2026
1h 40m
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Mitochondria Peptides: MOTS-c, Humanin, Genetic Variation in Health & Disease | Pinchas Cohen | Episode 304

12 Aug 2026
1h 46m
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Neuro-Immune Interactions: Pain, Inflammation, Peptides & Healing | Isaac Chiu | Episode 303

05 Aug 2026
1h 44m
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MOTS-c & Mitochondrial Peptides in Health & Aging | David Lee | Episode 302

30 Jul 2026
1h 50m
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Peptides & GHK-Copper in Skin Health | Rahi Sarbaziha | Episode 301

22 Jul 2026
50m
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Peptides & Blood-Brain Barrier in Health & Disease | William Banks | Episode 300

15 Jul 2026
1h 44m
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Iron Overload & Lipid Peroxidation in Cell Death & Neurodegenerative Disease | Pamela Maher | Episode 299

08 Jul 2026
1h 42m
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GLP-1s & Novel Peptides in Obesity, Diabetes & Metabolic Health | Katrin Svensson | Episode 298

30 Jun 2026
1h 34m
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Deuterium, Metabolic Water & Cancer | Gábor Somlyai | Episode 297

18 Jun 2026
1h 33m
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Do Antioxidant Supplements Promote Cancer? | Isaac Harris | Episode 296

11 Jun 2026
57m
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Fructose Metabolism in Obesity, Dementia, Evolution | Richard Johnson | Episode 295

04 Jun 2026
1h 36m
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How to Lie With Science: Seed Oils & Inflammation | M&M Livestream 1

27 May 2026
1h 12m
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Ancestry & Genetic Diversity in Human Fat Metabolism: Seed Oils & Omega Fats | Floyd Chilton | Episode 294

22 May 2026
1h 51m
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Pregnenolone & Corticosteroids in the Brain | Sherwood Brown | Episode 293

15 May 2026
1h 1m
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Omega Fats & ω-3 Supplements in Human Health | Bill Harris | Episode 292

08 May 2026
1h 46m
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