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Nick Jikomes · Health

Mind & Matter

Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it. The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today. Not medical advice. At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it. As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet. I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint. My beliefs: Taking ownership of your health starts with taking ownership of your information diet . All knowledge is provisional and we must work hard to prevent ourselves from becoming attached to our favorite ideas & preferred conclusions. Wisdom comes from an iterative, trial-and-error process of learning and unlearning. Letting go of pre-conceived notions can be painful, but pain is information. Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload & historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi: “Γνῶθι σεαυτόν” ( Know thyself ) “Μηδὲν ἄγαν” ( Nothing in excess) “Ἐγγύα πάρα δ Ἄτα” ( Certainty brings insanity)

Episodes

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Omega Polyunsaturated Fats in Inflammation | Philip Calder | Episode 291

01 May 2026
1h 55m
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Reversing Alzheimer's & Neurodegeneration: Latest Science | Andrew Pieper | Episode 290

24 Apr 2026
1h 24m
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How Parental Exercise Effects Offspring Health | Kristin Stanford | 289

17 Apr 2026
50m
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Vagus Nerve Stimulation & Inflammation | Kevin Tracey | 288

10 Apr 2026
1h 59m
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Light, Hunger & Mitochondria: Non-Image Forming Effects of Sunlight | Alexis Cowan | 287

03 Apr 2026
1h 50m
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Sleep, Brain Fat & Oxidative Stress | Amita Sehgal | 286

29 Mar 2026
1h 9m
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Peptides for Tissue Repair: BPC-157, TB-500 & the "Wolverine Stack"

22 Mar 2026
1h 5m
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Obesity Resistance & Leanness | Ep. 284

13 Mar 2026
1h 0m
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Mitochondria Genetics & Human Metabolic Variation in Health & Disease | Douglas Wallace

05 Mar 2026
1h 42m
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Bile Acids in Health & Metabolic Disease

28 Feb 2026
53m
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Circadian Rhythms, Metabolism & Why Timing Your Meals Matters | Dr. Joseph Bass

23 Feb 2026
1h 31m
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Opioid Addiction: RNA Biology, Brain Inflammation & Psychedelic Therapy

19 Feb 2026
1h 17m
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Estrogen & Body Fat: Menopause, Puberty, Females vs. Males

14 Feb 2026
1h 39m
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The Claustrum: Cognition, Consciousness, Alcohol & Psychedelics | 278

09 Feb 2026
1h 35m
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Psychedelic Neurobiology: Sex-Specific Effects of MDMA & Psilocybin in Addiction & Reward Behavior

05 Feb 2026
1h 10m
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AMPK: Biochemistry of Nutrient Sensing, Fasting, Cell Repair & Growth | Greg Steinberg

25 Jan 2026
1h 20m
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Farm Food: Soy in Animal Feed, Pesticides, Phytoestrogens, Seed Oils & Regenerative Farming

19 Jan 2026
1h 36m
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Personalized Nutrition: Individual Responses to Foods, Fiber, Fats & Maternal Health

14 Jan 2026
1h 20m
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Nutrition Content of Animal & Plant Foods: Beef, Plant-Based Meat, Raw vs. Processed Milk | Stephan Van Vliet

09 Jan 2026
1h 36m
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Obesogens & Oxidative Stress in Metabolic Health, Neurodegeneration & Alzheimer's Disease | Robert Lustig | 272

04 Jan 2026
2h 12m
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