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Nick Jikomes · Health

Mind & Matter

Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it. The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today. Not medical advice. At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it. As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet. I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint. My beliefs: Taking ownership of your health starts with taking ownership of your information diet . All knowledge is provisional and we must work hard to prevent ourselves from becoming attached to our favorite ideas & preferred conclusions. Wisdom comes from an iterative, trial-and-error process of learning and unlearning. Letting go of pre-conceived notions can be painful, but pain is information. Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload & historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi: “Γνῶθι σεαυτόν” ( Know thyself ) “Μηδὲν ἄγαν” ( Nothing in excess) “Ἐγγύα πάρα δ Ἄτα” ( Certainty brings insanity)

Episodes

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Carbohydrates vs Ketosis in Exercise, Fatigue & Sports Science | Andrew Koutnik | 271

31 Dec 2025
2h 9m
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Stress & Psilocybin: Effects on Maternal Care & Offspring Development | Danielle Stolzenberg | 270

26 Dec 2025
1h 51m
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Soybean Oil: Obesity, Fatty Liver Disease, Gut Health, IBS & Colitis | Frances Sladek | 269

21 Dec 2025
1h 50m
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Dietary Fat & Light Regulation of Circadian Biology | Louis Ptacek | 268

17 Dec 2025
1h 24m
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Ketosis & BHB: Metabolic Diet Therapies, Brain Cancer & Exercise | Dominic D'Agostino | 267

12 Dec 2025
1h 41m
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Seed Oils, Chronic Inflammation, Heart Health & Marijuana | Ganesh Halade | 266

07 Dec 2025
1h 30m
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Evaluating Science: Clinical Trials, Epidemiology, Preclinical Studies & Mendelian Randomization | George Davey Smith | 265

02 Dec 2025
1h 26m
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Psychoactive Drugs, Psychedelics, Society & Hamilton's Pharmacopeia | Hamilton Morris | 6

27 Nov 2025
2h 6m
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Energy Metabolism & Information Processing in the Brain | Luis Felipe Barros | 264

26 Nov 2025
1h 23m
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How & Why Mitochondria Make Their Own Fat | Sara Nowinski | 263

18 Nov 2025
57m
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Hormones & Instincts: Hunger, Aggression & Parenting Behavior | Jonny Kohl | 262

07 Nov 2025
1h 0m
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Mitochondrial Transfer, Obesity & Immune-Metabolism Interactions | Jon Brestoff | 261

02 Nov 2025
56m
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Energy Resistance Principle in Life, Healing & Disease | Martin Picard & Nirosha Murugan | 260

28 Oct 2025
2h 9m
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Menstrual & Lunar Cycle Synchrony, Circadian Rhythms | Charlotte Förster | 259

19 Oct 2025
57m
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Evolution of Bipedality, Human Pelvis, Muscle & Brain | Terence Capellini | 258

15 Oct 2025
1h 22m
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Sleep, Mitochondrial Metabolism & Oxidative Stress | Gero Miesenbock | 257

10 Oct 2025
1h 17m
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Bacterial Infection, Oral Hygiene, Atherosclerosis & Heart Disease | Pekka Karhunen | 256

05 Oct 2025
39m
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Unlocking Energy: How Nutrition & Drugs Impact Your Mitochondria | Chris Masterjohn | 255

30 Sep 2025
2h 6m
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How Genes & Environment Shape Your Brain: ApoE, Alzheimer's & Space Radiation | Jacob Raber | 254

26 Sep 2025
53m
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Maternal Obesity, Immune System, Fatty Liver Disease & Epigenetics | Elvira Mass | 253

21 Sep 2025
1h 13m
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