The Proof with Simon Hill

What Bone Density Scans Can't Tell You About Fracture Risk | A Masterclass on Bone Health

The Keto Study That Wasn't About Keto | Dr Nicola Guess

A recent Washington University study comparing ketogenic, Mediterranean, and plant-rich diets reveals that significant reductions in liver fat stem primarily from increased protein and reduced carbohydrate intake rather than ketosis. Dietitian Dr. Nicola Guess notes that while the ketogenic diet yielded positive result...

30 Years of Diet Trials: What a Stanford Scientist Is Most (and Least) Sure About | Dr Christopher Gardner

Nutrition science requires balancing the rigor of randomized controlled trials with the practical realities of human behavior and cultural food preferences. Stanford nutrition professor Christopher Gardner emphasizes that while isolated nutrient studies often yield null results, dietary patterns—such as those prioritiz...

My Plaque Protocol, and Why I Started a PCSK9 Inhibitor | Simon Hill, MSc

Atherosclerosis management requires a nuanced understanding of cumulative exposure and genetic risk rather than relying solely on current cholesterol levels. Despite maintaining a plant-based diet, regular exercise, and optimal sleep, persistent coronary artery plaque necessitates a shift from lifestyle-only management...

Why Your MRI Doesn't Mean You Need Surgery | Dr Howard Luks

Orthopaedic surgery often prioritizes surgical intervention, yet clinical evidence frequently supports conservative management for common conditions like meniscus and rotator cuff tears. Many findings on imaging, such as labral fraying or joint space narrowing, represent age-appropriate changes rather than acute pathol...

Birth, Breastfeeding, and the Truth About Baby Food | Dr Federica Amati

The Liver Disease 30% of Us Have and Never Feel | Prof Aleksander Krag

Steatotic liver disease, characterized by excess fat accumulation in the liver, affects approximately 30% of the global population and frequently progresses asymptomatically toward fibrosis and cirrhosis. Prof. Aleksander Krag emphasizes that while early detection is critical, the condition remains largely reversible i...

The Case for Treating Cholesterol Before Plaque Appears | Dr Thomas Dayspring and Dr Dan Soffer

Atherosclerosis is a ubiquitous condition driven by the accumulation of ApoB-containing lipoproteins in the arterial wall, necessitating early and aggressive risk management. While genetics and lifestyle factors like smoking, blood pressure, and insulin sensitivity influence individual susceptibility, the primary preve...

Bone Health, Falls, Medications & Healthy Longevity | Dr Deborah Kado

Longevity science centers on maintaining functional independence through a holistic approach that prioritizes individual goals over mere biological markers. Geriatrician Dr. Deborah Kado emphasizes the "4Ms" framework—what matters, medication, mentation, and mobility—to guide clinical care. Aging successfully involves ...

Type 2 Diabetes Remission in the GLP-1 Era | Prof Roy Taylor

Type 2 Diabetes is a reversible condition driven by chronic calorie excess that causes ectopic fat accumulation in the liver and pancreas, ultimately suppressing insulin-producing beta cells. Prof Roy Taylor’s Twin Cycle model explains that this metabolic dysfunction can be corrected through significant weight loss—typ...

Lowering Blood Sugar Without Weight Loss | Dr Nicola Guess

Calorie-independent dietary interventions offer a viable pathway for managing Type 2 diabetes and achieving remission, particularly for patients where significant weight loss is not clinically appropriate. Research led by dietitian and academic Dr. Nicola Guess demonstrates that high-protein, low-carbohydrate diets—spe...

The Fertility Test Most Men Are Never Offered | Dr Michael Eisenberg and Dr Natalie Crawford

Male fertility is a critical, often overlooked component of reproductive health that serves as a vital indicator of a man’s current and future physiological well-being. With male factors contributing to 50% of infertility cases, routine semen analysis is essential for identifying potential issues before they become chr...

Superagers, statins, the latest cholesterol pill and the truth about heart disease risk | Dr Terry Simpson

Cardiovascular health and metabolic disease management remain central to longevity, with a focus on lowering ApoB levels to stabilize arterial plaque. While lifestyle interventions like the MIND diet and resistance training are foundational for preventing cognitive decline and sarcopenia, pharmacological advancements s...

The Science of Metabolic Flexibility, Zone 2, and Reversing Diabetes | A Masterclass

Metabolic health centers on mitochondrial efficiency, where the ability to oxidize glucose and fats determines long-term health and longevity. Mitochondria act as the body's powerhouses, and their decay—often accelerated by sedentary lifestyles—underlies cardiometabolic diseases like type 2 diabetes. Lactate serves as ...

New Science of Weight Loss | A Masterclass

Obesity is a chronic, relapsing neuroendocrine disease rather than a failure of willpower. GLP-1 receptor agonists, such as Zepbound and Wegovy, effectively treat this condition by quieting "food noise"—the persistent, brain-driven urge to consume calories—thereby enabling patients to regain control over their eating b...

Fertility, Sperm Health, and Nutrition Before and During Pregnancy | Dr Federica Amati

The first thousand days of life—from conception through a child's second birthday—represent a critical "golden window" where environmental and nutritional inputs fundamentally shape long-term health and aging. Dr. Federica Amati, an expert in biomedical sciences and maternal nutrition, explains that this period, anchor...

Can You Reverse Heart Disease? What My Plaque Scans Showed | Dr Campbell Rogers

Coronary artery disease management is shifting from population-based risk scores toward direct, quantitative imaging of arterial plaque. Dr. Campbell Rogers, an interventional cardiologist and Chief Medical Officer at Heartflow, explains how AI-driven analysis of coronary CT angiography provides precise, patient-specif...

Reversing Artery Plaque: 8 Supplements Ranked by the Evidence | Simon Hill, MSc

Supplements for reversing atherosclerosis vary significantly in their clinical evidence and efficacy. High-dose purified EPA, specifically icosapent ethyl, stands out as the most effective intervention, with multiple imaging and outcome trials confirming its ability to shrink vulnerable plaque and reduce cardiovascular...

How to Lose Weight and Fix Your Metabolism in 2026 | Dr Mauricio Gonzalez

Metabolic health management requires balancing the rapid rise of GLP-1 medications with evidence-based lifestyle interventions. Dr. Mauricio Gonzalez, an internal medicine physician and endocrinology fellow, emphasizes that obesity functions as a neuroendocrine disease rather than a character flaw, necessitating a shif...

Evidence-Based Exercise in Pregnancy and Postpartum | Dr Margie Davenport