Derms on Drugs is where cutting-edge dermatology meets mediocre comedy. Each week three dermatologists – Matt Zirwas, Laura Ferris and Tim Patton – discuss, debate, and dissect the hottest topics in dermatology. It's everything you need to know to be on the cutting-edge of dermatology and it’ll be the most fun you’ve ever had while actually learning something useful. Derms on Drugs is produced by Scholars in Medicine, an online educational platform (scholarsinmedicine.com) exclusively for healthcare professionals of all levels of experience and education.
Dermatology research and clinical management strategies center on evidence-based approaches for complex skin conditions. High-dose ivermectin provides no clinical superiority over standard dosing for treating crusted scabies, while ultrasound and CT imaging offer comparable efficacy in detecting nodal metastases for ad...
Dermatology research and clinical management strategies take center stage as the hosts analyze emerging infectious diseases, pediatric conditions, and novel therapeutic approaches. Recent reports indicate a potential person-to-person transmission of Dermatophilus congolensis among men who have sex with men, necessitati...
Atopic dermatitis stems largely from environmental exposures rather than genetics, specifically the rise of toluene diisocyanate in car exhaust and synthetic fabrics since the 1970s. This chemical byproduct damages skin barrier function by altering the skin microbiome, explaining the urban-rural gradient and the surge ...
Psoriatic arthritis management requires a nuanced approach that balances skin clearance with the prevention of irreversible joint damage. The APEX study demonstrates that the IL-23 inhibitor guselkumab significantly inhibits radiographic progression, providing a potent therapeutic option for patients with active diseas...
Dermatology clinical practice and recent literature updates center on innovative treatment paradigms and safety reassurances for common conditions. A retrospective study on cutaneous T-cell lymphoma demonstrates that combining Brentuximab Vedotin with ultra-low-dose total skin electron beam therapy yields rapid, comple...
Vulvar dermatoses, specifically lichen sclerosus and genitourinary syndrome of menopause, require precise clinical management to prevent long-term complications. Lichen sclerosus necessitates consistent maintenance therapy with super-potent topical steroids to mitigate the elevated risk of squamous cell carcinoma, even...
Clinical research in dermatology reveals that bathing frequency—whether daily or weekly—does not significantly impact eczema severity, suggesting patient preference should guide practice. While Dupilumab is traditionally used for atopic dermatitis, emerging data indicates it may improve survival in cancer patients unde...
Regenerative dermatology and longevity medicine focus on restoring tissue to its original state rather than merely masking symptoms of aging. Systemic health, particularly hormonal balance, plays a critical role in skin integrity; bioidentical hormone replacement therapy offers a safe, evidence-based intervention for p...
Gene expression profiling using a 487-gene panel helps predict patient response to biologics versus JAK inhibitors in atopic dermatitis, offering a more precise approach to systemic therapy selection. Intralesional TVEC demonstrates efficacy in treating invasive cutaneous squamous cell carcinoma, with evidence of an ab...
Late-breaking abstracts from the American Academy of Dermatology meeting reveal significant advancements in dermatological therapeutics and diagnostic technology. Combination therapies, such as Ixekizumab with Terzapatide, demonstrate superior efficacy in managing psoriatic arthritis, while new JAK inhibitors like Povo...
Late-breaking clinical trial abstracts from the American Academy of Dermatology meeting reveal significant advancements and limitations in dermatological therapeutics. Roflumilast 0.05% cream demonstrates efficacy in infants with atopic dermatitis, while the STAT6 degrader KT-621 emerges as a promising, clean-profile a...
The DECIDE study indicates that the 31-gene expression profile test for cutaneous melanoma provides limited stratification for thicker tumors, leaving the clinical utility of sentinel lymph node biopsies for T1B lesions unresolved. Management of bullous pemphigoid remains contentious, with U.S. specialists favoring sys...
Hidradenitis suppurativa (HS) management requires early, aggressive intervention to prevent irreversible scarring and tunneling, shifting the focus toward a "window of opportunity" for biologic therapy. Dr. Chris Sayed, an HS expert, joins the panel to analyze recent clinical data, including two-year results for bimeki...
Dermatology experts analyze the clinical utility of 31-gene expression profiling for T1A and T1B melanomas, concluding that the test is often overused and lacks robust evidence to guide sentinel lymph node biopsy decisions. The discussion shifts to Extramammary Paget Disease, highlighting the efficacy of combining Mohs...
Cutaneous connective tissue diseases, particularly cutaneous lupus erythematosus (CLE) and dermatomyositis, present significant therapeutic challenges due to a lack of FDA-approved, standalone treatments. Deucravacitinib, a selective TIK2 inhibitor, demonstrates superior efficacy in CLE compared to placebo, with meta-a...
Acne management evolves with the 1726 nm laser, which demonstrates efficacy in moderate-to-severe cases over one year, though high costs limit its utility compared to systemic options like isotretinoin. Regarding pemphigus, maintenance therapy with mycophenolate mofetil following rituximab fails to improve remission ra...
Low-dose naltrexone offers potential benefits for pruritic dermatologic conditions like Hailey-Hailey disease and lichen planus, though vivid dreams remain a common side effect. While metformin provides metabolic improvements, it fails to yield superior clinical outcomes for hidradenitis suppurativa compared to doxycyc...
Atopic dermatitis functions as a multi-organ system disease, characterized by the "SINGE" framework—skin, immune, neuro, gastro, and endocrine interactions. While patients frequently seek dietary restrictions to manage flares, current evidence suggests that restrictive diets often lack clinical efficacy and may inadver...
The Mediterranean diet offers measurable benefits for mild-to-moderate psoriasis, reducing PASI scores and improving quality of life independent of weight loss. Clinical management of squamous cell carcinoma in kidney transplant recipients necessitates a stratified approach, where immunosuppression adjustments are rese...
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