When the Data Get Personal

Gene expression profiling using a 487-gene panel helps predict patient response to biologics versus JAK inhibitors in atopic dermatitis, offering a more precise approach to systemic therapy selection. Intralesional TVEC demonstrates efficacy in treating invasive cutaneous squamous cell carcinoma, with evidence of an abscopal effect that may reduce the development of future tumors. Expert consensus indicates that dupilumab unmasks pre-existing cutaneous T-cell lymphoma (CTCL) rather than causing it, necessitating biopsy-based screening for patients with late-onset disease or atypical clinical features. While methotrexate remains the standard for juvenile localized scleroderma, mycophenolate serves as a viable alternative with a more favorable side-effect profile. Furthermore, significant diagnostic delays in desquamative gingivitis underscore the necessity for improved interdisciplinary collaboration between dental and medical specialists to ensure timely diagnosis and management of oral inflammatory conditions.