Melanoma, EMPD, and a Prostate Drug Walk Into a Bar...

Dermatology experts analyze the clinical utility of 31-gene expression profiling for T1A and T1B melanomas, concluding that the test is often overused and lacks robust evidence to guide sentinel lymph node biopsy decisions. The discussion shifts to Extramammary Paget Disease, highlighting the efficacy of combining Mohs micrographic surgery with adjuvant radiation to reduce local recurrence rates to 3%. Furthermore, the conversation evaluates the use of bicalutamide for female pattern hair loss, noting its superior performance in trichoscopic hair density and diameter compared to spironolactone, despite the necessity for hepatic monitoring. Finally, the analysis addresses the association between chronic pruritus in diabetic patients and specific medications like dipeptidyl peptidase-4 inhibitors and statins, while cautioning against the over-diagnosis of drug-induced rashes when spongiosis is the primary clinical pattern.