Dave Asprey · Health

The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio , he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

Episodes

Sugar-Free Backlash, Taurine Fail, Copper Brain Therapy, Childhood Biohacking, Strength Training : 1488

19 Jun 2026

11m

BDNF Superpowers Through MDMA and Ketamine | Dr. Dave Rabin : 1486

18 Jun 2026

1h 1m

The Skin Mistakes That Age You Fast and Kill You Slow | Dr. Michael Christopher : 1485

16 Jun 2026

44m

Putin Longevity, Pancreatic Cancer Cure, AI Therapy, GLP-1 Breast Cancer... : 1479

05 Jun 2026

10m

How to Get Microplastics Out of Your Body | Mara Labs : 1478

04 Jun 2026

1h 1m

Peptide Power Without Needles: Smarter Dosing for Longevity | Justin Kirkland : 1477

02 Jun 2026

54m

AI processed

Peptides offer significant potential for health optimization, yet the industry suffers from quality control issues, supply chain opacity, and regulatory confusion. Justin Kirkland, a peptide synthesis expert from Amino Innovations, details how high-quality peptides require precise chemical synthesis rather than relianc...

Brain Fog Starts in Your Feet (Scientifically Proven) : 1476

31 May 2026

NASCAR Death, Steroid Olympics, Genetic Age Truth, and Gut Depression... : 1475

29 May 2026

Combine Creatine With THIS To Fight The Root Cause of Aging | Andrew Salzman : 1474

28 May 2026

1h 23m

AI processed

Aging originates in the gut, where progressive inflammation and mitochondrial dysfunction create a permeable barrier that allows bacterial toxins like flagellin to circulate and induce systemic damage. This process depletes NAD, primarily through the upregulation of the enzyme CD38 and PARP activation during DNA repair...