Dr. William Li: Eat to Beat Disease, Extend Longevity, and Hack Your Vascular Health

Your body already has a built-in cancer defense system, and the foods you eat can rival prescription drugs at activating it. In this episode, you'll discover what 720,000 living centenarians reveal about longevity, why microplastics are reaching your brain through your nose, and how your blood vessels hold the real key to biological aging.

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Host Dave Asprey sits down with Dr. William Li, an internationally renowned physician, scientist, and two-time New York Times bestselling author of "Eat to Beat Disease" and "Eat to Beat Your Diet." As President and Medical Director of the Angiogenesis Foundation, Dr. Li's groundbreaking research has led to the development of more than 40 new medical treatments impacting care for over 70 diseases including diabetes, heart disease, blindness, and obesity. His TED Talk, "Can We Eat to Starve Cancer?", has surpassed 11 million views, making him one of the most trusted voices at the intersection of functional medicine and food as medicine science.

Together they dig into the biology of SuperAgers, the vascular markers that predict how long you'll live, and why flow-mediated dilation may be the most underrated biohacking measurement tool available today. Dave shares what happened after four separate gene therapies, including klotho and VEGF, and Dr. Li explains why your metabolism, mitochondria, and gut microbiome show up in the data on every centenarian ever studied. They also get into the microplastic crisis, the cribriform plate pathway that delivers airborne particles directly to your brain, and why your tongue is the first place your body quietly stores fat.

You'll Learn:

What centenarian research reveals about immune function, gut health, and vascular resilience
Why 50% of food extracts matched or outperformed cancer drugs in head-to-head angiogenesis testing
How microplastics travel through your nose directly to your central nervous system
What flow-mediated dilation and pulse wave velocity tell you about your true biological age
Why your hind-third tongue fat is an overlooked early warning sign for sleep apnea and metabolism problems
What Dave's four gene therapies (klotho, VEGF, follistatin) actually did to his body
How the vagus nerve connects gut health to brain optimization, stress resilience, and longevity
Why genetics now accounts for roughly half of longevity outcomes, and what that means for the future of gene therapy
How to use biohacking tools to compound your health the same way you compound financial returns

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Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: William Li, Dr. William Li, Eat to Beat Disease, angiogenesis, food as medicine, centenarians, SuperAgers, longevity, anti-aging, biohacking, vascular health, flow-mediated dilation, pulse wave velocity, microplastics, cribriform plate, gene therapy, klotho, VEGF, follistatin, mitochondria, metabolism, gut health, vagus nerve, sleep apnea, functional medicine, human performance, brain optimization, cancer prevention, inflammation, immune system

Resources:

• Learn More About Dr. Li’s Work At: https://drwilliamli.com

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Timestamps:

00:00 – Trailer

02:33 – William's Background

06:21 – Food vs. Cancer Drugs

14:09 – Gene Therapy

23:50 – Centenarian Research

27:41 – Stress & the Vagus Nerve

37:31 – Vascular Health

42:34 – Microplastics

53:19 – Novel Biomarkers

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The Foods That Starve Cancer | William Li : 1481

The Human Upgrade: Biohacking for Longevity & Performance

The Foods That Starve Cancer | William Li : 1481