The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!
In this episode of the a16z Podcast, Anjney Midha and Sarah Wang interview OpenAI's Chief Scientist Jakub Pachocki and Chief Research Officer Mark Chen about GPT-5, the company's advancements in AI reasoning, and their pursuit of an automated researcher. They discuss the shift towards economically relevant benchmarks f...
In this panel discussion, Aaron Levie, Steven Sinofsky, and Martin Casado debate the merits of H-1B visa reforms, particularly the proposal of setting a price on these visas, and explore the implications for startups versus larger companies. The conversation shifts to the impact of AI on labor productivity, with person...
In this interview podcast, Dr. Jay Bhattacharya discusses new initiatives at the NIH, including a $50 million autism data science initiative, potential treatments using Leucovorin, and cautions regarding Tylenol use during pregnancy. The conversation explores the replication crisis in science, the need for bold funding...
In a panel discussion featuring Dylan Patel, Sarah Wang, and Guido Appenzeller, Erik Torenberg leads a conversation about the surprising collaboration between NVIDIA and Intel, including NVIDIA's $5 billion investment in Intel. The discussion explores the implications for AMD, ARM, and the global chip race. Dylan Patel...
This episode of Honestly features a discussion between Bari Weiss, Konstantin Kisin, and Katherine Boyle regarding the assassination of Charlie Kirk and its broader implications for American society. Katherine Boyle reflects on the idea of martyrdom and the need for individuals to stand up for their beliefs in the face...
In this a16z podcast episode, Alex Rampell and Justine Moore discuss the future of commerce in the age of AI, focusing on how AI agents could change online shopping habits. They explore the potential disruption of e-commerce, the impact on Google's advertising model, and the challenges and opportunities for merchants a...
In this episode of the a16z Podcast, Anjney Midha interviews Alexander Embiricos, product lead for Codex at OpenAI, about the origin, development, and future of Codex, OpenAI's coding agent. They discuss the evolution of Codex, its unique cloud-based form factor, and the safety considerations driving its design. They e...
In this episode of the a16z Podcast, Guido Appenzeller interviews Patrick Hsu, co-founder of the Arc Institute, and Jorge Conde, a16z general partner, about accelerating scientific progress through virtual cells and foundation models for biology. They discuss the challenges in making science faster, including incentive...
In this episode of Lenny's Podcast, Lenny Ritschitzky interviews Ben Horowitz, co-founder of a16z, about founder psychology, decision-making, hiring, and management. Ben shares insights on overcoming hesitation, making tough decisions, and the importance of building a strong company culture. He emphasizes the need for ...
In this a16z podcast episode, Angela Strange leads a discussion with Tim Mayopoulos, Mike Yu, and Andrew Wang about the technology infrastructure of the mortgage industry. The conversation explores why mortgage tech has been slow to innovate, the challenges of standardization and regulation, and the impact of outdated ...
In this a16z Consumer Pod episode, Anish Acharya and Chris Dixon discuss the power and history of consumer networks, the forces that shape their growth, and the implications for founders building in the age of AI. They explore exponential forces in tech like Moore's Law, composability, and network effects, and how thes...
In this episode of the a16z Podcast, Guido Appenzeller interviews Mark Cuban, exploring a range of topics from the impact of AI on social media and content creation to the future of healthcare and the dynamics of owning an NBA team in the streaming era. Cuban shares his insights on political messaging, emphasizing the ...
In this a16z podcast episode, Guido Appenzeller hosts Matt Perault, head of AI policy, and Colin McCune, head of government affairs, both at a16z, to discuss the Little Tech Agenda, a framework designed to support startups and smaller tech companies in the face of regulations often tailored for larger corporations. The...
In this episode, Alex Rattray, founder of Stainless API, joins a16z partner Jennifer Li to discuss the evolution of APIs and developer platforms. Alex draws parallels between APIs and the human brain, emphasizing their role as the connective tissue of the internet. The conversation explores the challenges developers fa...
In this episode of the Oprah Podcast, Oprah Winfrey interviews author Shaka Senghor about his new book, "How to Be Free," exploring the concept of freedom and escaping self-imposed limitations. Shaka shares his personal journey from incarceration to liberation, emphasizing the importance of forgiveness, resilience, and...
Martin Casado from a16z and Leo Polovets from Humba Ventures join the podcast to discuss the debate around consensus versus non-consensus investing in venture capital. They explore the meaning of consensus in practice, the efficiency of early markets, and the risks for founders who stray too far from consensus. The con...
In this episode of the Uncapped podcast, Jack Altman interviews Martin Casado, a general partner at a16z, about the evolving landscape of venture capital, the increasing importance of media for VCs, and a16z's shift from generalist to specialized platforms. They delve into the rise of AI infrastructure, discussing its ...
The a16z Podcast features Erik Torenberg, Chris Best (co-founder of Substack), Katherine Boyle, and Andrew Chen discussing the origin, cultural impact, and future vision of Substack. They explore Substack's role in supporting free speech, reinventing the business model for independent media, and saving blogging. The co...
In this episode of the Shawn Ryan Show, Katherine Boyle, a general partner at a16z and co-founder of the American Dynamism practice, discusses with Shawn the importance of venture capital in driving American innovation, particularly in defense, aerospace, manufacturing, energy, and critical infrastructure. Katherine sh...
In this interview podcast, Martin Casado, a general partner at a16z, discusses the current state of AI investing, emphasizing that zero-sum thinking is the primary pitfall. He highlights the creation of value at every layer of the AI stack and addresses the balance between monopolies and concentrated markets. Casado al...
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