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Colossus | Investing & Business Podcasts · Investment

Invest Like the Best with Patrick O'Shaughnessy

Conversations with the best investors and business leaders in the world. We explore their ideas, methods, and stories to help you better invest your time and money. Hear stock market and boardroom insights you can't find anywhere else. If you're a professional investor, CEO, entrepreneur, or business strategist, this is for you. Explore all our episodes and learn more at https://www.colossus.com

Episodes

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Noah Shinn - Building Instinct: The Personal Agent - [Invest Like the Best, EP.493]

28 Sep 2026
1h 26m
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Personal AI agents represent a fundamental shift in how humans interact with technology, moving from active application usage to proactive, goal-oriented assistance. Noah Shinn, founder of Instinct, describes a platform that functions as a personal assistant capable of executing complex tasks—such as travel booking, wa...

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Gabe Stengel - Building Investing Superintelligence - [Invest Like the Best, EP.492]

22 Sep 2026
1h 4m
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AI is fundamentally reshaping capital markets by transitioning from simple productivity aids to autonomous, firm-level infrastructure. Rogo founder Gabe Stengel emphasizes that successful vertical AI applications must move beyond general-purpose models to solve specific, complex financial workflows, such as deal-making...

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Michael Moritz - Lessons From 40 Years of Investing and Writing - [Invest Like the Best, EP.491]

16 Sep 2026
1h 12m
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Formative childhood experiences, particularly those occurring before age 14, serve as the primary architect of an individual's adult identity, drive, and resilience. Michael Moritz, former leader of Sequoia Capital, argues that understanding a person's heritage and early environment—such as the survivalist instincts in...

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Walter Russell Mead - How America Keeps Winning - [Invest Like the Best, EP.490]

08 Sep 2026
1h 14m
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American power remains resilient despite the crumbling of post-1945 institutional frameworks, driven by the nation's unique ability to harness technological revolutions. Walter Russell Mead, a historian and foreign policy expert, argues that the historical success of the English-speaking maritime order—from the Dutch t...

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Sarah Guo - What the 250 People Building AI Believe - [Invest Like the Best, EP.489]

01 Sep 2026
59m
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Navigating the current AI-driven investment landscape requires moving beyond traditional software metrics toward a fundamental understanding of capital-intensive sectors like energy, robotics, and biology. This shift necessitates a focus on "great person" theory, where high-agency individuals drive outcomes despite the...

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Neil Movva - Making AI 10x Cheaper - [Invest Like the Best, EP.488]

25 Aug 2026
1h 18m
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The future of artificial intelligence hinges on reducing the cost of inference to enable long-running, background agents that operate over hours or days rather than real-time human interactions. Neil Movva, founder of SAIL Research, argues that shifting from latency-optimized to throughput-optimized systems is essentia...

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Ben Thompson on Big Tech, China, and the AI Boom Running Out of Money - [Invest Like the Best, EP.487]

18 Aug 2026
1h 16m
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The AI landscape is currently defined by a delicate equilibrium where U.S. frontier labs maintain a lead while international competitors distill models, creating a sustainable, albeit tense, status quo. The massive capital expenditure in AI infrastructure mirrors historical railroad booms, yet the industry faces a pote...

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Eric Vishria - A Decade of Lessons Investing in Software & Hardware - [Invest Like the Best, EP.486]

11 Aug 2026
1h 5m
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AI infrastructure and enterprise adoption are undergoing a fundamental reordering, mirroring the shift from traditional SaaS to specialized, high-performance computing. Running large-scale models efficiently requires deep technical expertise, creating significant performance gaps between generic cloud providers and spe...

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Gavin Baker - AI Market Jitters - [Invest Like the Best, EP.485]

04 Aug 2026
1h 5m
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The AI infrastructure landscape is experiencing a disconnect between public market skepticism and accelerating fundamental demand for compute. GPU pricing and availability continue to tighten, as hyperscalers under-earn due to long-term contracts that prioritize supply chain security over short-term revenue. The prolif...

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Sam Altman - How to Make an Abundant Future - [Invest Like the Best, EP.484]

28 Jul 2026
53m
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OpenAI CEO Sam Altman reflects on the evolution of artificial intelligence, emphasizing the transition from broad experimentation to a focused strategy of providing abundant, cost-effective intelligence. The conversation centers on the critical decision to secure massive compute resources early, a move initially percei...

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Matthew Smith — Natural Gas: The Next Bottleneck - [Invest Like the Best, EP.483]

21 Jul 2026
56m
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The United States faces a looming, historic natural gas supply deficit by 2028, driven by the convergence of surging AI data center energy requirements and committed LNG exports. Matthew Smith, founder and CIO of Cronometer Partners, argues that current market complacency—rooted in a decade of gas abundance—ignores the...

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John Kim - How to Raise a Few Billion Dollars - [Invest Like the Best, EP.482]

14 Jul 2026
50m
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Fundraising functions as a sophisticated, trust-based discipline where capital flows to those who master the intersection of desire and risk mitigation. John Kim, a prolific fundraiser, defines the core equation of persuasion as desire minus fear, emphasizing that logical arguments are secondary to building deep, authe...

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Jeremy Giffon - The Billion Dollar PDF - [Invest Like the Best, EP.481]

07 Jul 2026
1h 15m
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Private markets are increasingly driven by narrative and the reflexive influence of the "timeline," where storytelling ability serves as the ultimate filter for fund success. Capital allocation has shifted from traditional billionaire worship toward a new priestly class of influential "posters" who dictate consensus an...

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Etched - Building AI Hardware to Make Inference Faster and Cheaper - [Invest Like the Best, EP.480]

30 Jun 2026
1h 27m
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Specialized AI inference hardware offers a path toward superior performance and cost-efficiency compared to general-purpose GPUs. Etched founders Gavin Uberti and Rob Wachen detail their strategy of extreme vertical integration, designing everything from chip architecture to rack systems and power delivery. Current har...

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Vlad Barbalat - Investing $120 Billion in Permanent Capital - [Invest Like the Best, EP.479]

23 Jun 2026
1h 9m
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Liberty Mutual Investments manages a $120 billion balance sheet, leveraging a mutual insurance structure to prioritize long-term capital deployment over short-term shareholder demands. This unique positioning enables the firm to maintain investment hygiene and act as a flexible, multi-dimensional capital provider acros...

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Kareem Amin - The Unusual Approach to Company Building - [Invest Like the Best, EP.478]

16 Jun 2026
56m
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Clay co-founder and CEO Kareem Amin details the evolution of his software company, which leverages AI to democratize programming for go-to-market teams. The conversation centers on the philosophical foundations of leadership, specifically the commitment to "truth, justice, and courage" as guiding principles for organiz...

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Alex Sacerdote - How to Invest Through Technology Cycles - [Invest Like the Best, EP.477]

09 Jun 2026
1h 10m
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Technology adoption follows S-curves, where identifying the inflection point of a new paradigm—like the current AI shift—allows for exponential earnings growth. Whale Rock Capital Management founder Alex Sacerdote applies this framework to navigate the AI stack, prioritizing chips and infrastructure before foundational...

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Dara Khosrowshahi - Uber's Bet on AVs, AI, and Building a Super-App - [Invest Like the Best, EP.476]

03 Jun 2026
1h 7m
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Uber CEO Dara Khosrowshahi details the company's evolution from a period of intense organizational chaos to a stable, high-growth entity generating over $10 billion in free cash flow. The conversation centers on Uber’s role as a demand aggregator in the emerging autonomous vehicle (AV) market, where the company leverag...

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Dan Loeb - Lessons from 30 Years of Investing - [Invest Like the Best, EP.475]

28 May 2026
1h 3m
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Dan Loeb, founder and CEO of Third Point, details the evolution of his investment strategy over three decades, transitioning from a focus on event-driven credit and distressed debt to a broader approach incorporating quality and thematic technology investing. The discussion highlights the necessity of adapting to rapid...

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Darren Farber on Iran, China, and the Rise of Neoprimes - [Invest Like the Best, EP.474]

26 May 2026
46m
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Defining victory in modern, open theaters of war requires balancing proportional force with the strategic necessity of industrial mobilization. Darren Farber, managing partner of defense-focused investment firm Albion River, argues that winning in regions like Iran involves degrading military capabilities while navigat...

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