No Priors: AI, Machine Learning, Tech, & Startups

No Priors Ep. 133 | With Alpha School Principal Joe Liemandt

No Priors Ep. 132 | With Decagon CEO and Co-Founder Jesse Zhang

No Priors Ep. 131 | With Jared Kushner

No Priors Ep. 130 | With OpenEvidence Founder Daniel Nadler

OpenEvidence functions as a specialized semantic search engine for high-stakes clinical decision-making, connecting physicians to landmark biomedical literature rather than providing generative answers. By treating doctors as consumers with agency, the platform addresses the unsustainable growth of medical knowledge, w...

No Priors Ep. 129 | With U.S. Under Secretary of State (E) Designate Jacob Helberg

In this episode of No Priors, Sarah and Elad interview Jacob Helberg, the Undersecretary of State Designate for Economic Growth, Energy, and the Environment. They discuss America's need to change its global supply chain, the importance of nuclear energy, the return of American manufacturing, and superintelligence as a ...

No Priors Ep. 128 | With DeepLearning.AI Founder Andrew Ng

In this episode of No Priors, Andrew Ng discusses the future of AI, emphasizing multiple vectors of progress beyond just scale, including agentic workflows and multimodal models. He clarifies his definition of "agentic AI" and addresses the obstacles to implementing true AI agents, highlighting the critical need for ta...

No Priors Ep. 127 | With SemiAnalysis Founder and CEO Dylan Patel

In this episode of No Priors, the host interviews Dillon Patel, Chief Analyst at Semianalysis, about various topics in the AI and chip infrastructure space. They discuss the implications of open source AI models, the challenges of building large-scale data centers, and the geopolitical aspects of AI technology. Patel s...

No Priors Ep. 126 | With Cloudfare CEO Matthew Prince

In this episode of No Priors, Matthew Prince, co-founder and CEO of Cloudflare, discusses the evolving internet landscape with the hosts, focusing on the shift from search-driven traffic to AI-centric models. Prince addresses the challenges content creators face as AI increasingly delivers derivative content, potential...

No Priors Ep. 125 | With Senior White House Policy Advisor on AI Sriram Krishnan

In this episode of No Priors, hosts Sarah Guo and Elad Gil interview Sriram Krishnan, a White House official and former tech executive, about the American AI Action Plan and the national implications of the AI race. They discuss the current position of the US in AI, the workforce and energy needs for future AI developm...

No Priors Ep. 124 | With SurgeAI Founder and CEO Edwin Chen

No Priors Ep. 123 | With ReflectionAI Co-Founder and CEO Misha Laskin

In this episode of No Priors, Misha Laskin, co-founder of ReflectionAI and former Google DeepMind researcher, discusses building superintelligent autonomous systems with a focus on co-designing products and research. Laskin details ReflectionAI's mission to create an "omniscient oracle" for organizations, starting with...

No Priors Ep. 122 | With Rippling Co-Founder & CEO Parker Conrad

No Priors Ep. 121 | With Chai Discovery Co-Founders Jack Dent and Joshua Meier

In this episode of No Priors, the hosts interview Josh Meyer and Jack Dent, co-founders of Chai Discovery, about their new Chai-2 zero-shot antibody discovery platform. They discuss the platform's capabilities, which include designing antibodies that bind to specified targets with significantly higher success rates tha...

No Priors Ep. 120 | With Google DeepMind’s Pushmeet Kohli and Matej Balog

In this episode of No Priors, Pushmeet Kohli and Matei Balag from DeepMind discuss AlphaEvolve, an AI coding agent that uses Gemini models and evolutionary search to discover new algorithms. They delve into the origins of this project, tracing its lineage from AlphaGo and AlphaTensor, and explain how AlphaEvolve differ...

No Priors Ep. 119 | With Applied Intuition's Qasar Younis and Peter Ludwig

No Priors Ep. 118 | With Anthropic Co-Founder Ben Mann

No Priors Ep. 117 | With Co-Director of Standord's HAI & Founder of World Labs Dr. Fei-Fei Li

Fei-Fei Li, a pioneer in computer vision and deep learning, discusses spatial intelligence and her new company, World Labs, which aims to create 3D world models. Spatial intelligence is defined as the ability to understand, reason, interact with, and generate 3D environments, mirroring how humans and animals perceive t...

No Priors Ep. 116 | With Sarah and Elad

No Priors Ep. 115 | With Glean Founder and CEO Arvind Jain

No Priors Ep. 114 | With Duolingo CEO Luis von Ahn

In this episode of No Priors, Sarah interviews Luis von Ahn, the co-founder and CEO of Duolingo, about the company's approach to education, AI, and motivation. Luis discusses Duolingo's evolution into teaching math, music, and chess, driven by the goal of making learning accessible and engaging. He emphasizes the impor...