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No Priors: AI, Machine Learning, Tech, & Startups · Technology

No Priors: AI, Machine Learning, Tech, & Startups

Your guide to the AI revolution, co-hosts Elad Gil and Sarah Guo talk to the world's leading engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? Email feedback to [email protected]. Sarah Guo is a startup investor and the founder of Conviction, an investment firm purpose-built to serve intelligent software, or "Software 3.0" companies. She spent nearly a decade incubating and investing at venture firm Greylock Partners. Elad Gil is a serial entrepreneur and a startup investor. He was co-founder of Color Health, Mixer Labs (which was acquired by Twitter). He has invested in over 40 companies now worth $1B or more each, and is also author of the High Growth Handbook.

Episodes

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From Note-Taking App to AI Workspace: The Simon Last Interview

12 Mar 2026
29m
AI processed

Notion’s integration of artificial intelligence marks a fundamental shift from building tools for human productivity to creating platforms where humans manage autonomous agents. The transition began with simple writing assistants and evolved into complex, index-based Q&A systems capable of querying diverse data sources...

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Who's Actually Funding the AI Buildout?

26 Feb 2026
36m
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The massive build-out of AI infrastructure requires shifting from traditional equity-heavy models to creative debt structures that leverage contracted cash flows from investment-grade counterparties. Neil Tiwari of Magnetar Capital highlights that while chip supply constraints have eased, the industry now faces critica...

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The AI Code Slop: Risk or Opportunity?

19 Feb 2026
40m
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AI, R2 and the Future of Everyday Driving | Rivian CEO RJ Scaringe

12 Feb 2026
31m
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How AI Will Transform Roblox Games into Photorealistic Worlds | CEO David Baszucki

05 Feb 2026
43m
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How Until is Engineering Away Time in Organ Transplants | Laura Deming

29 Jan 2026AI processed

Laura Deming, co-founder and CEO of Until, discusses the frontier of reversible cryopreservation, beginning with human organs and progressing to whole-body hibernation. The primary goal is to create a new form of critical care, providing an "ambulance for the future" by hibernating individuals until a cure for their di...

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No Priors Live: Is the SaaS "Bear Thesis" Overblown? MongoDB CEO Answers

22 Jan 2026
36m
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The Largest Untapped Market Inside U.S. Defense | Emil Michael

15 Jan 2026
44m
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NVIDIA’s Jensen Huang on Reasoning Models, Robotics, and Refuting the “AI Bubble” Narrative

08 Jan 2026AI processed

The podcast explores the transformative impact of AI across various sectors, addressing both optimistic and pessimistic narratives surrounding its development. It highlights AI's role in creating new industries like chip manufacturing and AI factories, while also augmenting existing professions such as radiology, where...

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No Priors Ep. 144 | The 2026 AI Forecast with Sarah & Elad

19 Dec 2025AI processed

In this episode of No Priors, Sarah Guo and Elad Gil discuss and predict trends in AI, robotics, IPOs, consumer experiences, and defense for the year 2026. They touch on the adoption of AI in various sectors like medicine and law, potential market reactions to NVIDIA's performance, and the future of robotics with insig...

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No Priors Ep. 143 | With ElevenLabs Co-Founder Mati Staniszewski

11 Dec 2025
41m
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No Priors Ep. 142 | With Harvey Co-Founder and President Gabe Pereyra

05 Dec 2025
44m
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In this episode of the podcast, Gabe Pereyra, the founder of Harvey, discusses the company's AI-driven solutions for law firms and in-house legal teams. He explains how Harvey has evolved from an individual lawyer productivity tool to a platform that enhances team collaboration and overall law firm profitability. Gabe ...

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No Priors Ep. 141 | With Sunday Robotics Co-Founders Tony Zhao and Cheng Chi

19 Nov 2025
39m
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In this episode of No Priors, Sarah Guo interviews Tony Zhao and Cheng Chi, co-founders of Sundae, about their work on Memo, a general home robot. They discuss the current state of AI and robotics, focusing on the shift from classical robotics to more generalizable AI algorithms. The conversation covers their research ...

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No Priors Ep. 140 | With Benchling Co-Founder and CEO Sajith Wickramasekara

13 Nov 2025AI processed

In this episode of No Priors, Sarah Guo interviews Sajith Wickramasekara, the co-founder and CEO of Benchling, a software company focused on biotech R&D. Sajith discusses Benchling's role in modernizing scientific processes, from molecule design to data analysis, and its impact on the biotech and pharmaceutical industr...

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No Priors Ep. 139 | With Snowflake CEO Sridhar Ramaswamy

06 Nov 2025
42m
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In this episode of No Priors, Sarah Guo interviews Sridhar Ramaswamy, CEO of Snowflake, about his first 18 months in the role and the company's shift to becoming AI-first. Sridhar discusses the tactical changes he implemented, focusing on accountability and faster iteration, and how Snowflake is positioning itself as t...

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No Priors Ep. 138 | The Best of 2025 (So Far) with Sarah Guo and Elad Gil

31 Oct 2025
18m
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No Priors Ep. 137 | With Warp Co-Founder & CEO Zach Lloyd

23 Oct 2025
27m
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In this episode of No Priors, Elad Gil interviews Zach Lloyd, the co-founder and CEO of Warp, about AI dev tooling, human consciousness, and the future of coding. They discuss the societal impacts of AI, the distinction between intelligence and consciousness, and the limitations of the Turing test. Zach shares his insi...

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No Priors Ep. 136 | Base Power CEO and Co-Founder Zach Dell

15 Oct 2025
31m
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No Priors Ep. 135 | With Humans& Founder Eric Zelikman

09 Oct 2025
36m
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No Priors | With Palo Alto Networks CEO & Former Chief Business Officer of Google Nikesh Arora

02 Oct 2025
58m
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