The Peter Attia Drive

#208 - Tragedy, grief, healing, and finding happiness | Kelsey Chittick

#207 - AMA #35: "Anti-Aging" Drugs — NAD+, metformin, & rapamycin

This is a sneak peek of an Ask Me Anything (AMA) episode of The Drive Podcast, hosted by Peter Attia, featuring Nick Stenson and Matt Kaeberlein. The episode focuses on the science of aging, specifically discussing three geroprotective molecules: NAD (and its precursors NR and NMN), rapamycin, and metformin. The discus...

#206 - Exercising for longevity: strength, stability, zone 2, zone 5, and more

This podcast episode emphasizes the importance of exercise for longevity. The host discusses training for longevity by incorporating stability, strength, and low-end aerobic energy system into routines. Backcasting is introduced as a method to envision physical abilities and health at age 100 and work backward to maint...

#205 - Energy balance, nutrition, & building muscle | Layne Norton, Ph.D. (Pt.2)

Energy balance remains a thermodynamic constant, though individual metabolic responses vary due to factors like gut microbiome composition and non-exercise activity thermogenesis (NEAT). While tracking calories and macronutrients provides a necessary baseline for weight management, metabolic adaptation—such as reduced ...

#204 - Centenarians, metformin, and longevity | Nir Barzilai, M.D.

In this episode of The Drive Podcast, Peter Attia interviews Dr. Nir Barzilai, a longevity researcher, for the third time. They delve into two main topics: centenarians and metformin. The discussion on centenarians focuses on longevity genes like GH, IGF-1, CTEP, FOXO, TSHR, and APOE, and whether environment or genetic...

#203 - AMA #34: What Causes Heart Disease?

Atherosclerotic cardiovascular disease (ASCVD) represents the most significant threat to human longevity, functioning as an inevitable condition that affects nearly everyone who lives long enough. Contrary to the common perception that it is exclusively a disease of the elderly, over 50% of men and one-third of women s...

#202 - Peter on nutrition, disease prevention, sleep, and more — looking back on the last 100 episodes

In remembrance of Sarah Hallberg, D.O., M.S. (Ep. #162 Rebroadcast)

#201 - Deep dive back into Zone 2 | Iñigo San-Millán, Ph.D. (Pt. 2)

This podcast episode explores the physiological factors that contribute to elite cycling performance, with a focus on the training methods and testing protocols used to assess and develop athletes' capabilities. The conversation highlights the importance of lactate clearance, sustained power output, and fat oxidation i...

#200 - AMA #33: Hydration—electrolytes, supplements, sports drinks, performance effects, and more

Hydration physiology centers on the distribution of water across distinct body compartments, with intracellular fluid accounting for approximately two-thirds of total body water. The remaining volume resides primarily in the interstitial space and the vascular system. Tonicity dictates fluid movement across cell membra...

#199 - Running, overcoming challenges, and finding success | Ryan Hall

Elite long-distance runner Ryan Hall details his transition from record-breaking marathoner to strength-focused athlete, illustrating the physiological toll of extreme aerobic training. During his professional career, Hall maintained a sub-2:05 marathon pace, yet suffered from clinically low testosterone and chronic in...

#198 - Eye health—everything you need to know | Steven Dell, M.D.

The eye functions as a sophisticated camera, where the cornea and lens focus light onto the retina, a metabolically active tissue that converts photons into neural signals. Aging inevitably degrades this system, primarily through the hardening of the lens, which leads to presbyopia and eventually cataracts. While catar...

#197 - The science of obesity & how to improve nutritional epidemiology | David Allison, Ph.D.

#196 - AMA #32: Exercise, squats, deadlifts, BFR, and TRT

Maintaining a consistent exercise regimen requires a structured macro-cycle that balances cardiovascular health with strength training. Weekly routines prioritize Zone 2 and Zone 5 cardio sessions alongside a dedicated upper-lower body lifting split. Blood flow restriction (BFR) training serves as a critical finisher, ...

#195 - Freedom, PTSD, war, and life through an evolutionary lens | Sebastian Junger

#194 - How fructose drives metabolic disease | Rick Johnson, M.D.

Fructose metabolism functions as an evolutionary survival mechanism that triggers fat storage by creating a transient intracellular energy deficit through rapid ATP depletion. This process, driven by the enzyme fructokinase, is exacerbated by endogenous fructose production from glucose and salt via the polyol pathway, ...

#193 - AMA #31: Heart rate variability (HRV), alcohol, sleep, and more

Heart rate variability (HRV) serves as a critical metric for assessing the balance between the sympathetic and parasympathetic nervous systems. By measuring the millisecond-level variation between successive heartbeats, specifically the root mean square of successive differences (RMSSD), one can gauge autonomic tone. A...

#192 - COVID Part 2: Masks, long COVID, boosters, mandates, treatments, and more

#191 - Revolutionizing our understanding of mental illness with optogenetics | Karl Deisseroth M.D., Ph.D.

#190 - Paul Conti, M.D.: How to heal from trauma and break the cycle of shame