#204 - Centenarians, metformin, and longevity | Nir Barzilai, M.D.

In this episode of The Drive Podcast, Peter Attia interviews Dr. Nir Barzilai, a longevity researcher, for the third time. They delve into two main topics: centenarians and metformin. The discussion on centenarians focuses on longevity genes like GH, IGF-1, CTEP, FOXO, TSHR, and APOE, and whether environment or genetics play a more significant role in their long lifespans. They also explore what can be learned from centenarians about preventing diseases and improving healthspan. The conversation then shifts to a detailed examination of metformin, including the TAME trial, its impact on exercise, and its potential mechanisms of action, while also touching on epigenetic clocks and NAD precursors.