At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world's leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? “No Priors” is your guide to the AI revolution. Email feedback to [email protected]. Sarah Guo is a startup investor and the founder of Conviction, an investment firm purpose-built to serve intelligent software, or "Software 3.0" companies. She spent nearly a decade incubating and investing at venture firm Greylock Partners. Elad Gil is a serial entrepreneur and a startup investor. He was co-founder of Color Health, Mixer Labs (which was acquired by Twitter). He has invested in over 40 companies now worth $1B or more each, and is also author of the High Growth Handbook.
In this episode of No Priors, Kyle Vogt interviews Pushmeet Kohli and Matej Balag, the creators of AlphaEvolve, an AI coding agent that uses Gemini models and evolutionary search to discover new algorithms. They discuss the origins of AlphaEvolve, its differences from previous projects like AlphaTensor and FunSearch, a...
In this episode of No Priors, Elad interviews Qasar Younis and Peter Ludwig from Applied Intuition, a profitable AI company focused on building vehicle intelligence for cars, trucks, tanks, and fighter jets. They discuss the company's three business lines: engineering tools, a vehicle operating system, and autonomy app...
In this episode of No Priors, Ben Mann, a co-founder of Anthropic and former early engineer at OpenAI, discusses the Claude 4 release and Anthropic's approach to AI model development, safety, and deployment. Mann explains the art behind version releases, highlighting improvements in coding capabilities, agentic tasks, ...
In this episode of No Priors, Dr. Fei-Fei Li, a pioneer in computer vision and deep learning, discusses her new company, World Labs, and its focus on developing spatially intelligent AI through 3D world models. She defines spatial intelligence as the ability to understand, reason, interact with, and generate 3D environ...
Sarah and Elad discuss the AI market, noting a recent consolidation in areas like foundation models, healthcare services, and coding, while sales productivity, finance, and accounting remain open. They explore reasons for potential startup mergers to combat incumbents, citing ego, integration concerns, and valuation co...
This episode explores the evolution of enterprise search and knowledge management with Arvind Jain, CEO and co-founder of Glean, highlighting the transformative impact of Large Language Models (LLMs). Jain discusses how LLMs have shifted search from a static, keyword-based paradigm to one that deeply understands user q...
This episode explores the evolution and future of Duolingo, from its origins as a PhD project focused on making language learning accessible, to its current status as a diversified education app teaching math, music, and soon, chess. Luis von Ahn, co-founder and CEO, discusses the initial problem of learner motivation ...
This episode explores the advancements in OpenAI's O3 reasoning model, a significant leap in AI's ability to solve complex, multi-step tasks. Against the backdrop of previous models that primarily predicted the next token, O3 incorporates reinforcement learning, enabling it to think before responding and utilize vario...
This episode explores the development and capabilities of OpenAI's Deep Research, a new agentic product released in February. Isa Fulford, a key developer, details its origins, stemming from internal advancements in reinforcement learning algorithms initially applied to math and coding problems. The team then shifted...
This episode explores the challenges and innovations in mineral exploration, specifically focusing on KoBold Metals' approach. Against the backdrop of dwindling success rates in traditional mineral exploration, KoBold leverages AI and vast geoscience datasets to improve the discovery of critical minerals like lithium ...
This episode explores the future of AI model training data and its impact on the labor market, featuring Brendan Foody, co-founder and CEO of Mercor, a company specializing in recruiting individuals to train AI models. Against the backdrop of Mercor's rapid growth and $100 million funding, the discussion centers on th...
This episode explores the rapid advancements in AI image generation and their implications for various industries and the broader technological landscape. Against the backdrop of recent market fluctuations, the hosts discuss the ongoing evolution of AI image generation, noting the significant leaps in quality and cont...
This episode explores the transformative impact of AI on healthcare delivery, specifically focusing on Abridge, an AI company that processes medical conversations to alleviate clinicians' administrative burdens. Against the backdrop of a critical shortage of healthcare professionals and widespread clinician burnout, A...
This podcast features an interview with Chelsea Finn, co-founder of Physical Intelligence, a robotics company aiming to create general-purpose AI for robots. The conversation covers Finn's background in robotics, Physical Intelligence's approach to building a foundation model for robot control using diverse real-world...
This podcast interviews Thomas Dohmke, GitHub's CEO, focusing on GitHub Copilot's recent advancements and future development. The conversation covers the new "Agent Mode," which allows Copilot to autonomously execute tasks within VS Code, and teases "Project Padawan," aiming for Copilot to independently manage GitHub ...
This podcast interviews Dan Hendrycks, an AI researcher, about AI safety and its geopolitical implications. The conversation covers the roles of AI labs versus independent safety organizations, the differences between AI alignment and safety, and the potential weaponization of AI in cyber warfare, biological weapons d...
This podcast interviews Noubar Afeyan, founder and CEO of Flagship Pioneering, a firm behind Moderna and other biotech companies. The discussion covers Afeyan's entrepreneurial journey, his "emergent innovation" approach to building startups (emphasizing variation, selection, and iteration over rigid planning), and th...
This podcast interviews the CEOs and CTOs of the Arc Institute and Vevo about the release of Tahoe-100, the largest single-cell drug-perturbed dataset ever created. The discussion covers the significance of this dataset for advancing AI in biology, the need for virtual cell models alongside protein structure predictio...
This podcast features an interview with Kyle Vogt, a serial entrepreneur, focusing on his experiences founding Twitch and Cruise, and his current venture, The Bot Company, which develops consumer robots. The conversation covers Vogt's journey building Cruise, from its lean startup beginnings to its acquisition by GM, ...
This podcast features an interview with Winston Weinberg, co-founder and CEO of Harvey, an AI company focusing on domain-specific AI for legal and professional services. The conversation covers Harvey's origin story, its product strategy (building an expandable and collapsible AI platform), the challenges of building...
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