At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world's leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? “No Priors” is your guide to the AI revolution. Email feedback to [email protected]. Sarah Guo is a startup investor and the founder of Conviction, an investment firm purpose-built to serve intelligent software, or "Software 3.0" companies. She spent nearly a decade incubating and investing at venture firm Greylock Partners. Elad Gil is a serial entrepreneur and a startup investor. He was co-founder of Color Health, Mixer Labs (which was acquired by Twitter). He has invested in over 40 companies now worth $1B or more each, and is also author of the High Growth Handbook.
In this episode of No Priors, Sarah Guo interviews Sajith Wickramasekara, the co-founder and CEO of Benchling, about the intersection of AI and biotechnology. Sajith discusses Benchling's role in providing software for biotech R&D, the macro trends affecting the biotech industry including the rise of Chinese biotech co...
In this episode of No Priors, Sarah interviews Sridhar Ramaswamy, CEO of Snowflake, about his first 18 months in the role and Snowflake's shift to becoming an AI-first company. Sridhar discusses the company's transformation, embracing AI, and retooling marketing and go-to-market strategies. He shares his initial tactic...
This episode of "No Priors" reflects on key moments and insights from the podcast in 2025, highlighting conversations with leaders and experts in AI and related fields. The discussion includes Harvey CEO Winston Weinberg's early discovery of GPT-3's legal applications, Dr. Fei-Fei Li's perspective on spatial intelligen...
In this episode of No Priors, Elad Gil interviews Zach Lloyd, the co-founder and CEO of Warp, about AI dev tooling, human consciousness, and the future of coding. They discuss the nature of AI, distinguishing between intelligence and consciousness, and debate whether AI has the potential to become sentient. Zach shares...
In this episode of No Priors, Elad interviews Zach Dell, the founder and CEO of Base Power, about his company's mission to lower the cost of electricity and create energy abundance. Zach discusses Base Power's recent $1 billion fundraise and how the capital will be used to accelerate vertical integration, including des...
In this episode of No Priors, Sarah Guo interviews Eric Zelikman, formerly of Stanford and XAI, about his research contributions to reasoning and scaling up reinforcement learning (RL), as well as his new company, humans&. Zelikman discusses his motivation to build technology that empowers people to focus on their pass...
In this episode of No Priors, Sarah Guo and Elad Gil interview Nikesh Arora, CEO of Palo Alto Networks, about the future of search, the challenges and opportunities presented by generative AI and agentic AI, and the evolving landscape of cybersecurity. Arora shares his insights on how Google might transition its search...
In this episode of No Priors, Sarah Guo and Elad Gil interview Joe Lamont, founder of Trilogy and principal of Alpha School, about his vision for revolutionizing education. Lamont discusses his journey from AI entrepreneurship to education, driven by the potential of AI to scale personalized learning. He details Alpha ...
In this episode of No Priors, Elad Gil interviews Jesse Zhang, co-founder and CEO of Decagon, an AI customer service agent company. Zhang discusses Decagon's evolution from serving digital native companies to large enterprises like banks and airlines, driven by the demand for AI in customer service. He highlights the c...
In this episode of No Priors, Sarah Guo and Elad Gil interview Jared Kushner, discussing his investing firm Affinity Partners, his new AI venture BrainCo, and his experiences in government. Kushner details Affinity's global investment strategy, emphasizing identifying undervalued countries like Albania and applying AI ...
In this episode, Danielle discusses OpenEvidence, a clinical knowledge platform used by a significant portion of US doctors, emphasizing its role in high-stakes clinical decision support. She explains how it functions as a semantic search engine, providing relevant medical literature snippets to physicians facing compl...
In this episode of No Priors, Sarah and Elad interview Jacob Helberg, the Undersecretary of State Designate for Economic Growth, Energy and the Environment. They discuss America's need to change its global supply chain, the importance of nuclear energy, the return of American manufacturing, and the role of superintelli...
In this episode of No Priors, Andrew Ng discusses the future of AI, emphasizing multiple vectors of progress beyond just scale, including agentic workflows and multimodal models. He clarifies his term "agentic AI," noting the rapid marketing hype but also the real business progress, and identifies talent as the biggest...
In this episode of No Priors, Sarah interviews Dylan Patel, Chief Analyst at Semianalysis, about the latest developments in chips and AI infrastructure. They discuss the implications of open source AI models, particularly OpenAI's recent release, and debate whether model optimization will become a commodity, shifting c...
The podcast features a discussion with Matthew Prince, CEO of Cloudflare, about the evolving internet landscape, particularly the shift from search-based value creation to AI-driven interfaces. Prince addresses concerns about content creators' ability to monetize their work as AI increasingly uses derivative content, p...
In this episode of No Priors, Sarah Guo and Elad Gil interview Sriram Krishnan, a White House policy advisor on AI, about the national implications of the AI race. They discuss America's current position, the workforce and energy needs for the future, and strategies to win in AI. Krishnan shares insights into the devel...
In this episode of No Priors, Sarah and Elad interview Edwin Chen, the CEO of Surge, a bootstrapped human data startup that has achieved over a billion in revenue. Edwin discusses Surge's focus on high-quality human data for AI advancement, contrasting it with the "body shop" approach of competitors. He shares his expe...
In this episode of No Priors, Sarah interviews Misha Laskin, co-founder of ReflectionAI and former leader at Google DeepMind, about building superintelligent autonomous systems. Misha discusses ReflectionAI's mission to co-design products and research, focusing on solving real-world problems with their code comprehensi...
In this episode of No Priors, Sarah interviews Parker Conrad, the co-founder and CEO of Rippling, about his experiences and insights on building a successful company. Parker reflects on lessons learned from Zenefits, emphasizing the importance of regulatory compliance and a software-driven approach overreliance on oper...
In this episode of No Priors, Sarah interviews Josh Meyer and Jack Dent, co-founders of Chai Discovery, about their new AI-driven antibody discovery platform, Chai-2. Josh and Jack discuss the breakthroughs that led to the creation of Chai-2, including advancements in protein structure prediction and generative models....
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