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Michael Kennedy · Technology

Talk Python To Me

Talk Python to Me is a weekly podcast for Python developers, data scientists, and AI builders, hosted by developer and entrepreneur Michael Kennedy. We dive deep into the packages, tools, and people shaping Python, from web development and data science to AI and LLMs. If you're new to Python, you'll quickly learn the ins and outs of the community by hearing from its leaders. And if you've been Pythoning for years, you'll hear about your favorite packages and the hot new ones coming out of open source.

Episodes

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#568: Cloudflare Python Workers

03 Nov 2026
1h 2m
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Python Workers are now generally available on Cloudflare, enabling developers to execute Python code at the edge using WebAssembly. By integrating Pyodide—a Python runtime for the browser—with Cloudflare’s global network of over 350 locations, this platform facilitates low-latency execution of Python applications. Gues...

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#567: Personal AI Agents for Pythonistas

27 Oct 2026
1h 6m
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#566: State of the art in Python 2026

17 Oct 2026
1h 5m
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#565: Tachyon, Python 3.15's Built-in Sampling Profiler

02 Oct 2026
1h 27m
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#564: EVE Online Departs for Python 3

22 Sep 2026
1h 7m
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EVE Online is undergoing a massive technical migration, transitioning its 2.4 million lines of code from a custom Stackless Python 2 implementation to modern Python 3.12. This project involves navigating complex legacy dependencies, including 100 gigabytes of pickled Python objects stored in the database that must surv...

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#563: Getting Started with Rust as Python Devs

16 Sep 2026
1h 10m
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#562: DuckLake: The Lakehouse That's Just SQL and Parquet

10 Sep 2026
1h 11m
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DuckLake simplifies data lake management by replacing complex metadata file structures with a SQL-based catalog, enabling efficient querying of Parquet files. Unlike traditional OpenTable formats like Iceberg, which often require multiple round-trips to object storage, DuckLake utilizes a database-backed catalog to res...

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#561: TonIO, a Multi-threaded Async Runtime for Python

04 Sep 2026
1h 15m
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#560: Building a Research OS: From Django to 30,000 Samples

26 Aug 2026
1h 2m
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#559: 12 Things You Should (and Shouldn't) Do in AWS

19 Aug 2026
1h 7m
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Proactive cloud infrastructure management and security are critical to preventing catastrophic, high-stakes outages. Adopting Infrastructure as Code (IaC) tools like Terraform eliminates the risks associated with manual, undocumented provisioning, while granular Identity and Access Management (IAM) roles replace danger...

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#558: Hyper-Personal Software with Python

10 Aug 2026
1h 2m
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"Hyper-team software" addresses the prevalence of "dark matter" enterprise tools—small, neglected, or outdated internal applications that often remain untouched due to fear of breaking them. By leveraging AI-assisted development, small teams can rapidly modernize these systems or build new, lightweight solutions that i...

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#557: Security of everything at PyCon 2026

02 Aug 2026
1h 8m
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#556: Updates on Django's Async Story

26 Jul 2026
1h 4m
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#555: Marimo Pair - A Canvas for Agent + Developers Collaboration

13 Jul 2026
1h 4m
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#554: Trustworthy AI in Healthcare and Longevity

10 Jul 2026
1h 0m
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#553: All of our tools

26 Jun 2026
55m
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#552: Astral joins OpenAI

17 Jun 2026
1h 5m
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#551: Stroll Down Startup Lane - 2026

11 Jun 2026
1h 48m
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#550: AI Contributions and Maintainer Load in Open Source

30 May 2026
1h 2m
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#549: Great Docs

25 May 2026
1h 7m
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