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Madrona Ventures · Business

Founded & Funded

Listen to conversations between Madrona investors and entrepreneurs, founders, and startup personalities who talk about some of the key moments in building a company. Designed to give would-be founders and others interested in working with or for startups a view into the struggle and the lessons learned, these conversations are informal and informative. With more than 25 years of investing in early-stage technology companies, Madrona has worked with founders from day one to help build their company for the long run. We invest in seed and Series A companies in the Pacific Northwest building across the information technology spectrum and in Acceleration (B and beyond) stage companies building with AI, regardless of geography.

Episodes

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Is Your Startup Idea Too Early, Or the Wrong Thing?

05 Nov 2026
19m
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Concurrence aims to transform healthcare by building a causal understanding of human health, enabling systems to learn continuously from every patient interaction. By shifting away from narrow, transactional point solutions like revenue cycle management, the company focuses on creating a longitudinal, patient-centric i...

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The Legal Decisions Every AI Founder Needs to Get Right

14 Oct 2026
23m
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Is AI a Bubble? What PitchBook's Head of Research Sees in the Data

13 Aug 2026
39m
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Why AI Made Your Buyers Harder to Sell To

23 Jul 2026
30m
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The Best Infrastructure Moment Since Cloud

10 Jun 2026
41m
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AGI Needs Formal Reasoning. Carina Hong is Building it at Axiom.

13 May 2026
41m
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Palantir Alum Explains How AI is Used and Bought by the Federal Government

22 Apr 2026
35m
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Zapier Has More AI Agents Than Employees. Here's How That Happened

02 Apr 2026
43m
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Twitter's Ex-CEO: The Web Was Built for Humans — Let's Make it Work for AI Agents

18 Mar 2026
25m
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How to Sell AI Into the Enterprise: Pilots, Pricing, and Closing 12-Month Deals

04 Mar 2026
38m
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The Infrastructure of Intelligence: Inside Crusoe's Massive AI Factory in Texas

19 Feb 2026
23m
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Can We Trust AI? The Future of Verified Reasoning in High-Stakes Systems

22 Jan 2026
33m
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Microsoft's Agent Factory: The Future of AI Software with EVP of Core AI Jay Parikh

07 Jan 2026
29m
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How — and What — to Build in the Age of OpenAI

20 Nov 2025
28m
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The Analyst Mindset in Venture: Madrona Investor Rasik Parikh's story

05 Nov 2025
21m
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Redefining Communication: Yoodli Founders on AI Roleplays, Confidence & Building in Seattle

23 Oct 2025
37m
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From Google and Amazon to NewDays: Why These Tech Vets Bet on AI for Dementia

08 Oct 2025
42m
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The Future of Biology Is Generative: Inside Synthesize Bio's RNA AI Model

24 Sep 2025
32m
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From $1M to $10M ARR in 6 Months: How Fyxer is Winning AI Productivity

10 Sep 2025
20m
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Autonomous CRM: How Clarify Is Reinventing a $100B Category

21 Aug 2025
36m
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