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Daphne Zohar, Josh Schimmer, Brad Loncar, Tim Opler and more · Science

Biotech Hangout

A weekly discussion of all things biotech – breaking news, data, deals, and FDA actions – with a community of biotech industry leaders and experts. Join the live streams hosted by @BiotechCH, @daphnezohar, @bradloncar and @biotech1 on Twitter Spaces every Friday at 12pm ET.

Episodes

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Episode 198 - October 2, 2026

02 Oct 2026
1h 0m
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Public biotech markets remain resilient, with the XBI index significantly outperforming broader healthcare and tech benchmarks despite recent volatility. Strategic partnerships define current industry momentum, highlighted by the Regeneron-Sanofi collaboration extension and AstraZeneca’s $2 billion equity investment in...

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Episode 197 - September 25, 2026

25 Sep 2026
58m
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The biotech sector faces a complex landscape defined by shifting market dynamics, evolving regulatory policies, and significant clinical trial readouts. While small-cap performance has pressured long-short funds, the IPO market remains robust, signaling continued investor interest. Policy discussions center on Most Fav...

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Episode 196 - September 18, 2026

25 Sep 2026
55m
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The biotech industry currently navigates a complex landscape defined by shifting capital flows, the integration of AI, and evolving regulatory environments. While AI agents demonstrate potential for both innovation and security risks, the sector remains focused on therapeutic development rather than broader existential...

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Episode 195 - September 11, 2026

15 Sep 2026
1h 0m
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The biotech sector faces significant volatility as rising interest rates and energy prices weigh on the XBI index, shifting focus back to macroeconomic sensitivity. Regulatory stability emerges with the permanent appointments of Michael Davis to CDER and Kareem to CBER, signaling a transition toward more predictable ag...

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Episode 194 - August 28, 2026

28 Aug 2026
1h 1m
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Biotech capital markets remain resilient, with significant M&A activity offsetting policy uncertainty and a shifting IPO landscape. Big Pharma’s patent cliff continues to drive aggressive deal-making, even as acquisition premiums compress. Clinical developments dominate the sector, highlighted by Moderna’s positive mel...

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Episode 193 - August 14, 2026

14 Aug 2026
59m
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Public biotech markets remain healthy but increasingly discerning, as investors prioritize companies with robust clinical data over broad sector rallies. Biotech is emerging as a potential hedge against AI-related market volatility, though the sector remains highly sensitive to individual data readouts. Recent clinical...

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Episode 192 - August 7, 2026

07 Aug 2026
1h 3m
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The biotech industry faces a shifting landscape defined by market volatility, a surge in IPO activity, and evolving regulatory pressures. Recent speculation regarding potential mega-mergers, such as the rumored AstraZeneca and Bristol Myers deal, highlights concerns over capital efficiency and the potential for reduced...

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Episode 191 - July 31, 2026

03 Aug 2026
1h 0m
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Biotech sector performance remains volatile, with the XBI index experiencing recent pressure despite strong year-to-date gains compared to broader market indices. Robust M&A activity continues to drive the industry, fueled by large pharmaceutical companies seeking to address patent expirations and revenue gaps. AI inte...

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Episode 190 - July 24, 2026

24 Jul 2026
58m
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Biotech capital markets are witnessing a shift toward earlier-stage IPOs and an increase in reverse mergers, signaling rising risk tolerance despite a departure from the peak valuations of 2021. While companies like Scribe and Mentari leverage these pathways to access public capital, the long-term durability of these s...

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Episode 189 - July 17, 2026

17 Jul 2026
58m
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Episode 188 - July 10, 2026

10 Jul 2026
1h 0m
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Biotech industry leaders analyze recent market volatility and shifting regulatory landscapes, specifically focusing on the FDA's potential retrenchment regarding Complete Response Letter (CRL) transparency and the implications of leadership changes. The discussion highlights the integration of AI in drug discovery, not...

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Episode 187 - June 26, 2026

26 Jun 2026
1h 0m
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The biotech sector is currently experiencing a robust rally, fueled by strong fundamentals and a more permissive FDA regulatory environment. While M&A remains a primary driver of value, a shift is occurring as some companies prioritize long-term independence to build sustainable, revenue-generating businesses. Cross-bo...

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Episode 186 - June 12, 2026

12 Jun 2026
1h 1m
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Biotech market performance remains resilient, with the XBI index outperforming the S&P 500 year-to-date despite recent volatility. The IPO landscape shows signs of recovery, characterized by high-quality, data-driven offerings and a growing trend of dual-track processes where private companies weigh public listings aga...

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Episode 185 -June 5, 2026

09 Jun 2026
1h 0m
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Biotech industry performance currently faces headwinds as capital migrates toward AI-driven sectors, though long-term sector recovery remains supported by robust M&A activity. Legislative proposals like the Biotech Investment National Security Act threaten to restrict global collaboration and limit U.S. patient access ...

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Episode 184 - May 29, 2026

29 May 2026
58m
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The biotech industry is experiencing a resurgence in IPO activity, characterized by a shift toward late-stage clinical assets that suggest a maturing, albeit cautious, market. Central to current industry discourse is the tension between cost-efficient global outsourcing and the national security implications of offshor...

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Episode 183 - May 15, 2026

15 May 2026
1h 1m
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The biotech industry is experiencing a paradigm shift as China evolves from a low-cost development partner into a source of high-quality, validated innovation, forcing U.S. firms to rethink their competitive strategies. While AI-driven platforms like Isomorphic Labs attract massive capital, the transition from computat...

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Episode 182 - May 8, 2026

08 May 2026
1h 0m
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The biotech industry faces a complex landscape defined by record-breaking secondary offerings, shifting investor appetites, and significant regulatory volatility. While strong clinical data continues to drive capital inflows, the rapid pace of M&A—highlighted by the acquisition of Candid Therapeutics—underscores the st...

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Episode 181 - May 1, 2026

08 May 2026
1h 0m
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The biotech sector maintains positive year-to-date performance, with the XBI index outperforming broader markets despite recent volatility. The IPO window remains open for high-quality, long-incubated companies, evidenced by ten successful debuts raising $3.2 billion. M&A activity continues to accelerate, driven by Eli...

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Episode 180 - April 17, 2026

17 Apr 2026
53m
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The biotech sector is currently experiencing a robust period of growth, characterized by strong public market performance, an opening IPO window, and significant M&A activity. Clinical data remains the primary driver of investor sentiment, with companies like Revolution Medicines and Spyre demonstrating the market's ap...

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Episode 179 - April 10, 2026

10 Apr 2026
59m
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