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swyx + Alessio · Technology

Latent Space: The AI Engineer Podcast

The podcast by and for AI Engineers! In 2025, over 10 million readers and listeners came to Latent Space to hear about news, papers and interviews in Software 3.0. We cover Foundation Models changing every domain in Code Generation, Multimodality, AI Agents, GPU Infra and more, directly from the founders, builders, and thinkers involved in pushing the cutting edge. Striving to give you both the definitive take on the Current Thing down to the first introduction to the tech you'll be using in the next 3 months! We break news and exclusive interviews from OpenAI, Anthropic, Gemini, Meta (Soumith Chintala), Sierra (Bret Taylor), tiny (George Hotz), Databricks/MosaicML (Jon Frankle), Modular (Chris Lattner), Answer.ai (Jeremy Howard), et al. Full show notes always on https://latent.space Sponsorship and business inquiries: [email protected] www.latent.space

Episodes

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Synthesis Superintelligence: from Semiconductors to Superconductors — Periodic Labs’ Liam Fedus and Ekin Dogus Cubuk

08 Oct 2026
1h 24m
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Academia is for Ambition — Alex Zhang, MIT

02 Oct 2026
1h 41m
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Why Dwarkesh is Wrong about Computer Use + How OpenAI shipped its Jev competitor in 1 Week

30 Sep 2026
39m
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Claude Code’s Next Era — Thariq Shihipar, Anthropic

29 Sep 2026
1h 32m
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OpenRouter: from Seed to Stripe — with OpenRouter’s Alex Atallah & AMP’s Anjney Midha

25 Sep 2026
1h 20m
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OpenRouter functions as a critical distribution layer for the AI ecosystem, bridging the gap between model labs and developers by providing a unified, neutral marketplace for inference. By abstracting the complexities of endpoint management, versioning, and cost-efficiency, the platform enables rapid adoption of fronti...

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Runway’s WorldPrompt and the Engineering of Real-Time Worlds

25 Sep 2026
1h 36m
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🔬Bio-security is an AI Arms Race - Eric Nguyen (CEO, Radical Numerics)

23 Sep 2026
1h 31m
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🔬 An Oscar, Two Asteroids, and the Algorithm in Your sklearn: John Platt on AI for Science

22 Sep 2026
2h 1m
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Jev: System One models for Prod, not God — with Diogo Almeida, CEO, TypeSafe AI

21 Sep 2026
2h 20m
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Underwriting Superintelligence: Backing Agents you can Sue — Rune Kvist, AIUC

16 Sep 2026
1h 26m
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Frontier AI adoption faces a critical bottleneck: the lack of trust and liability frameworks. Rune Kvist, founder of AIUC, addresses this by building "confidence infrastructure" through standardized technical testing and insurance. AIUC1, an agent certification framework, requires quarterly simulations to verify safety...

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Humanity’s Last Invention — Richard Socher of Recursive

14 Sep 2026
1h 32m
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The "Eureka Machine" represents a vision for superintelligence capable of automating scientific and technological discovery, shifting AI development toward recursive self-improvement. Richard Socher, founder of Recursive, contends that superintelligence should be marketed for its transformative potential in fields like...

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🔬“We have foundation models for language, not for physics” — Anima Anandkumar, Bren Professor of Computing

26 Aug 2026
1h 23m
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Simulation: the new Scaling Law — Joon Sung Park, Simile AI

21 Aug 2026
1h 9m
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🔬The BioAI Phase Shift - Matthew McPartlon & Neil Patil, Chai Discovery

11 Aug 2026
1h 35m
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The Inference Engineering Masterclass — Philip Kiely & Ali Taha, Baseten

03 Aug 2026
1h 41m
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Inference engineering has evolved from simple model deployment into a complex, integrated discipline where training and inference are increasingly unified. Optimizing large language model performance requires a multi-layered approach, including cache-aware routing, speculative decoding, and precise quantization strateg...

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Codex from 0 to 10M Users: Building ChatGPT Work — Akshay Nathan, OpenAI

28 Jul 2026
1h 9m
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Inside the Model Factory — Eiso Kant, Poolside AI

23 Jul 2026
1h 54m
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Building foundation models requires an industrialized "model factory" approach that prioritizes engineering rigor, data immutability, and rapid experimentation cycles. Poolside, led by Eiso Kant, emphasizes that model building is primarily an engineering challenge rather than purely theoretical research. By treating da...

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🔬Causal Models Need Causal Data - Xaira’s X-Cell model for Drug Discovery (Bo Wang & Ci Chu, Chief Discovery Officer & Chief AI Scientist)

21 Jul 2026
1h 29m
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🔬 The Lab of the Future Should Feel Like a Data Center — Andy Beam & Rafa Gómez-Bombarelli, Lila Sciences

16 Jul 2026
1h 41m
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Why AI Infrastructure must evolve for Agent Experience — Akshat Bubna, Modal CTO

08 Jul 2026
57m
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Modal functions as a specialized cloud platform for AI applications, evolving from a general-purpose serverless runtime into a high-performance infrastructure provider for inference, training, and agentic workflows. By co-locating infrastructure requirements directly within code via decorators, the platform eliminates ...

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