After helping lead AI adoption at Moderna, Brice Chalamel has a new goal at OpenAI: help create 1,000 AI adoption success stories across large organizations.

Brice takes Henrik and Jeremy inside how work happens at OpenAI, where Slack has largely replaced internal email, agents help process information and draft responses, and some workflows are already moving agent to agent. But as AI takes on more responsibility, Brice argues that trust can’t be mandated. It has to be earned.

The conversation goes beyond tools into what it actually takes to lead people through change. Brice explains why, in a ten-step journey, nine steps may only be halfway, why our existing mental models shape how we respond to AI, and why leaders need to listen before trying to change someone’s mind.

They also explore Brice’s idea that AI could move us from “knowledge workers” to “intelligence workers,” a personal story about his mother using ChatGPT while caring for his father with Alzheimer’s, and why the benefits of AI need to extend beyond the people already living in abundance.

Key Takeaways

Trust in AI has to be earned
As agents take on more responsibility, people need experience with them before they’re willing to hand over judgment and communication.
AI adoption is a mind game and a heart game
Successful change depends not just on what people know about AI, but on what they believe, fear, and care about.
Nine steps can be only halfway there
The final stage of transformation is often where the hardest work begins and assumptions need to be questioned.
We’re moving from knowledge workers to intelligence workers
As AI handles more information processing, human value shifts toward judgment, perspective, influence, and decision-making.
Listen before you think
Changing minds starts with understanding the experiences and mental models behind someone’s point of view, not simply making a better argument.

Brice's LinkedIn: linkedin.com/in/bricechallamel/
Website: powerofwhy.ai

00:00 Intro: From Knowledge Worker to Intelligence Worker
00:30 Meet Brice Chalamel
01:18 From Moderna to OpenAI
04:50 The Mission: 1,000 AI Success Stories
07:45 How Work Happens at OpenAI
08:59 When Agents Talk to Agents
10:56 Trust Has to Be Earned
15:22 Brice’s Principles for Change
16:45 Nine Steps Is Halfway There
25:21 The Mind Game
30:24 Why Leaders Resist AI
35:28 The Human Side of AI
37:37 When ChatGPT Became a Lifeline
41:56 From Knowledge Worker to Intelligence Worker
43:37 Agency in the AI Era
46:31 Who Gets to Benefit From AI?
51:39 What Our Fear of AI Reveals
56:18 Listen Before You Think
01:03:07 The Debrief

📜 Read the transcript for this episode:

For more prompts, tips, and AI tools. Check out our website: https://www.beyondtheprompt.ai/ or follow Jeremy or Henrik on Linkedin:

Henrik: https://www.linkedin.com/in/werdelin
Jeremy: https://www.linkedin.com/in/jeremyutley

Show edited by Emma Cecilie Jensen.

From Knowledge Worker to Intelligence Worker: Why Human Judgment Matters More With AI - with OpenAI’s Brice Challamel

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From Knowledge Worker to Intelligence Worker: Why Human Judgment Matters More With AI - with OpenAI’s Brice Challamel