Bryan Johnson: I Just Took the Most Powerful Dose of DMT in the World... Here's What It Was Like

Bryan Johnson discusses his experiences with psychedelics, specifically 5-MeO-DMT, as a longevity experiment. Johnson describes the experience as encountering raw consciousness and intelligence, dwarfing any dynamic experience he's had. He notes that 5-MeO-DMT annihilated his default mode network, leading to a childlike state of excitement and renewal. Johnson also shares data from psilocybin experiments, revealing a metabolic reset in the brain and reduced inflammation, linking these effects to potential longevity benefits. He acknowledges the risks of psychedelics, emphasizing the need for quantified, supervised, and safe settings. The conversation further explores future longevity modalities like cell and gene therapy, mitochondrial rejuvenation, and Bryan Johnson organoids.