NEJM This Week — October 30, 2025

This episode of NEJM This Week covers a range of medical topics, including a 23-year follow-up on the European Prostate Cancer Screening Study, advances in lung cancer therapy with amavantamab lisertinib and osimertinib, and a randomized trial of physical therapy for meniscal tear and knee pain. It also discusses a promising vaccine for Salmonella Paratyphi A. The podcast further explores non-invasive liver fibrosis assessment, a complex lymphoma case, and perspectives on concierge care, kidney disease equity, WIC enrollment, community health initiatives, and FDA regulation. Additionally, it addresses the U.S. medical community's stance on the situation in Gaza, and presents clinical images of herpes simplex virus blepharitis and a nasal leech.