This New England Journal of Medicine podcast episode from August 7th, 2025, covers a range of medical topics. It includes discussions on treatments for chronic kidney disease and type 2 diabetes using finerenone with empagliflozin, bubonic plague treatments comparing ciprofloxacin and aminoglycosides, and advancements in treating advanced breast cancer with VEPTEGASTRANT and camizestrant. The podcast also addresses hypogonadism in men, a clinical problem-solving case of gasping for strength leading to a diagnosis of Lambert-Eaton myasthenic syndrome, and perspectives on the infant mortality rate, profit-driven medicine, lead contamination in Milwaukee schools, training health communicators, and the influence of the TV show ER on a physician's career choice. Additionally, it features medical images related to e-cigarette-associated lung injury and crusted scabies.
Part 1: Clinical Trials & Research
Part 2: Medical Practice & Problem Solving
Part 3: Public Health & Historical Context
Part 4: Reflections & Clinical Images
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