Aging, mTOR, Sirtuins, Rapamycin, Metformin, the Truth of Resveratrol & Longevity Supplements, David Sinclair & Anti-Aging Myths | Matt Kaeberlein | 151 | Mind & Matter

The podcast explores the science of aging, examining factors influencing longevity across species and within individuals. Matt Kaeberlein, CEO of OptiSpan, discusses the evolutionary perspective on aging, highlighting the roles of body size, metabolic rate, and reproductive viability. He notes the mysteries surrounding longevity mechanisms in outlier species like naked mole rats, and the impact of growth pathways like mTOR and IGF-1 on lifespan. Kaeberlein cautions against oversimplified interpretations of caloric restriction and advocates for a proactive, preventative approach to healthcare, emphasizing the need for a paradigm shift towards prioritizing healthspan. He also addresses common misconceptions around supplements like resveratrol and NMN, and advocates for routine testing of vitamin D, B12, Omega-3, and hormone levels.

Outlines

Part 1: Introduction, Aging Biology

Part 2: Mechanisms of Aging, Growth Pathways

Part 3: Nutrition, Metabolism, Caloric Restriction

Part 4: Terminology, Scientific Skepticism

Part 5: Longevity Interventions, Rapamycin

Part 6: Sirtuins, NAD+, Resveratrol

Part 7: Supplements, Metformin, Field Integrity

Part 8: Diagnostics, Practical Applications

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Aging, mTOR, Sirtuins, Rapamycin, Metformin, the Truth of Resveratrol & Longevity Supplements, David Sinclair & Anti-Aging Myths | Matt Kaeberlein | 151

Mind & Matter

Part 1: Introduction, Aging Biology

The Mission of OptiSpan: Proactive, Preventative Healthcare Through Aging Biology

Comparative Aging: Body Size, Metabolic Rate, and Evolutionary Perspectives

Longevity Outliers: Naked Mole Rats, Hyaluronic Acid, and Subterranean Adaptations

Part 2: Mechanisms of Aging, Growth Pathways

Programmed Aging vs. Byproduct: mTOR, Growth, and Reproductive Viability

Within-Species Body Size and Aging: Growth Pathways and Organ-Specific Effects

Growth Hormone Mutations, Social Status, and the Complexity of Human Aging

Hormone Replacement Therapy, Protein Intake, and the Limitations of Lab Models

Part 3: Nutrition, Metabolism, Caloric Restriction

Protein, mTOR, and Caloric Intake: Balancing Muscle Mass and Overall Health

Protein Intake, Tissue-Specific Aging, and Personalized Preventative Therapies

Caloric Restriction: Genotype Dependence, Timing, and Social Implications

Part 4: Terminology, Scientific Skepticism

Reversing Aging: Terminology, Expectations, and the Need for Comprehensive Data

Sloppy Terminology, Misleading Claims, and the Importance of Context

Part 5: Longevity Interventions, Rapamycin

Rapamycin: Discovery, Mechanisms, and the Shift in Aging Research

Rapamycin's Effects: Inflammation, Autophagy, and Potential Side Effects

mTOR in the Brain: Learning, Memory, and Off-Label Rapamycin Use

Part 6: Sirtuins, NAD+, Resveratrol

Sirtuins: Discovery, Function, and the Evolutionarily Conserved Longevity Model

Sirtuins and NAD Precursors: Hype, Reality, and the Importance of Replication

Resveratrol: Origins, Activation, and the Substrate-Specific Activation Theory

Resveratrol's Bioavailability and the Meta-Analysis of Lifespan Studies

Part 7: Supplements, Metformin, Field Integrity

Taurine: Decreasing Levels with Age and the Need for Replication

Metformin: Mechanisms, Mouse Studies, and Potential Side Effects

Contamination of the Aging Field and the Importance of Skepticism

Part 8: Diagnostics, Practical Applications

Supplements, Biological Aging Tests, and the Importance of Functional Measurements

Blood Markers, Nutritional Deficiencies, and the Importance of Hormone Testing

OptiSpan's Mission, Recommended Experts, and the Need for a Paradigm Shift

Aging, mTOR, Sirtuins, Rapamycin, Metformin, the Truth of Resveratrol & Longevity Supplements, David Sinclair & Anti-Aging Myths | Matt Kaeberlein | 151

Mind & Matter

Part 1: Introduction, Aging Biology

00:24The Mission of OptiSpan: Proactive, Preventative Healthcare Through Aging Biology

The Mission of OptiSpan: Proactive, Preventative Healthcare Through Aging Biology

04:42Comparative Aging: Body Size, Metabolic Rate, and Evolutionary Perspectives

Comparative Aging: Body Size, Metabolic Rate, and Evolutionary Perspectives

08:50Longevity Outliers: Naked Mole Rats, Hyaluronic Acid, and Subterranean Adaptations

Longevity Outliers: Naked Mole Rats, Hyaluronic Acid, and Subterranean Adaptations

Part 2: Mechanisms of Aging, Growth Pathways

14:56Programmed Aging vs. Byproduct: mTOR, Growth, and Reproductive Viability

Programmed Aging vs. Byproduct: mTOR, Growth, and Reproductive Viability

21:54Within-Species Body Size and Aging: Growth Pathways and Organ-Specific Effects

Within-Species Body Size and Aging: Growth Pathways and Organ-Specific Effects

26:03Growth Hormone Mutations, Social Status, and the Complexity of Human Aging

Growth Hormone Mutations, Social Status, and the Complexity of Human Aging

30:32Hormone Replacement Therapy, Protein Intake, and the Limitations of Lab Models

Hormone Replacement Therapy, Protein Intake, and the Limitations of Lab Models

Part 3: Nutrition, Metabolism, Caloric Restriction

37:56Protein, mTOR, and Caloric Intake: Balancing Muscle Mass and Overall Health

Protein, mTOR, and Caloric Intake: Balancing Muscle Mass and Overall Health

42:27Protein Intake, Tissue-Specific Aging, and Personalized Preventative Therapies

Protein Intake, Tissue-Specific Aging, and Personalized Preventative Therapies

46:17Caloric Restriction: Genotype Dependence, Timing, and Social Implications

Caloric Restriction: Genotype Dependence, Timing, and Social Implications

Part 4: Terminology, Scientific Skepticism

53:02Reversing Aging: Terminology, Expectations, and the Need for Comprehensive Data

Reversing Aging: Terminology, Expectations, and the Need for Comprehensive Data

57:25Sloppy Terminology, Misleading Claims, and the Importance of Context

Sloppy Terminology, Misleading Claims, and the Importance of Context

Part 5: Longevity Interventions, Rapamycin

1:00:59Rapamycin: Discovery, Mechanisms, and the Shift in Aging Research

Rapamycin: Discovery, Mechanisms, and the Shift in Aging Research

1:06:26Rapamycin's Effects: Inflammation, Autophagy, and Potential Side Effects

Rapamycin's Effects: Inflammation, Autophagy, and Potential Side Effects

1:17:23mTOR in the Brain: Learning, Memory, and Off-Label Rapamycin Use

mTOR in the Brain: Learning, Memory, and Off-Label Rapamycin Use

Part 6: Sirtuins, NAD+, Resveratrol

1:21:23Sirtuins: Discovery, Function, and the Evolutionarily Conserved Longevity Model

Sirtuins: Discovery, Function, and the Evolutionarily Conserved Longevity Model

1:28:24Sirtuins and NAD Precursors: Hype, Reality, and the Importance of Replication

Sirtuins and NAD Precursors: Hype, Reality, and the Importance of Replication

1:35:30Resveratrol: Origins, Activation, and the Substrate-Specific Activation Theory

Resveratrol: Origins, Activation, and the Substrate-Specific Activation Theory

1:44:51Resveratrol's Bioavailability and the Meta-Analysis of Lifespan Studies

Resveratrol's Bioavailability and the Meta-Analysis of Lifespan Studies

Part 7: Supplements, Metformin, Field Integrity

1:47:48Taurine: Decreasing Levels with Age and the Need for Replication

Taurine: Decreasing Levels with Age and the Need for Replication

1:51:26Metformin: Mechanisms, Mouse Studies, and Potential Side Effects

Metformin: Mechanisms, Mouse Studies, and Potential Side Effects

1:58:40Contamination of the Aging Field and the Importance of Skepticism

Contamination of the Aging Field and the Importance of Skepticism

Part 8: Diagnostics, Practical Applications

2:03:05Supplements, Biological Aging Tests, and the Importance of Functional Measurements

Supplements, Biological Aging Tests, and the Importance of Functional Measurements

2:17:20Blood Markers, Nutritional Deficiencies, and the Importance of Hormone Testing

Blood Markers, Nutritional Deficiencies, and the Importance of Hormone Testing

2:23:30OptiSpan's Mission, Recommended Experts, and the Need for a Paradigm Shift

OptiSpan's Mission, Recommended Experts, and the Need for a Paradigm Shift