541: Can a Pill Help You Live Longer? The Science Behind NAD and Longevity | Robert Fried | The Genius Life

The podcast explores the role of NAD, a crucial molecule for cellular energy, mitochondrial function, and DNA repair, in health and aging. Robert Fried, CEO of True Niagen, discusses how NAD levels decline with age and metabolic stress, impacting the body's ability to produce energy and repair damage. He highlights research indicating that elevating NAD levels via nicotinamide riboside (NR) can improve mitochondrial biogenesis and cellular resilience. Fried cautions against direct NAD supplementation due to bioavailability issues, advocating for NR precursors like Niagen. The conversation touches on potential applications of NAD research in Parkinson's disease, cosmetics, and fatigue-related conditions like long COVID, while also addressing concerns about cancer risk and the importance of quality certifications in the supplement industry.

Outlines

Part 1: Introduction to NAD and Cellular Health

Part 2: Scientific Research and the NR Pathway

Part 3: Origins, Background, and Longevity Strategy

Part 4: Future Outlook, AI, and Healthspan

Part 5: Practical Applications and Conclusion

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541: Can a Pill Help You Live Longer? The Science Behind NAD and Longevity | Robert Fried

The Genius Life

Part 1: Introduction to NAD and Cellular Health

NAD: The Molecule Central to Cellular Energy, Mitochondrial Function, and DNA Repair

NAD's Role in Energy Production, Mitochondrial Health, and Cellular Repair

The Relationship Between Declining NAD Levels, Aging, and Cellular Performance

NAD as an Aging Biomarker and its Impact on Healthspan

Part 2: Scientific Research and the NR Pathway

Animal and Human Studies on NAD and its Potential in Treating Diseases

NAD, NR, and the Discovery of the NR Kinase Pathway

Expectations and Scientific Approach to TruNiagen Supplementation

Supplement Quality, Bioavailability, and the Problem of Misinformation

Part 3: Origins, Background, and Longevity Strategy

NR in Dairy and Robert Fried's Background

Robert Fried's Journey into the Longevity Space and NAD Research

The Future of NAD Research in Pharma, Biotech, and Cosmetics

NAD Supplementation, Cancer Risk, and Niacin

Part 4: Future Outlook, AI, and Healthspan

Erasing BS Narratives in Longevity and the Pursuit of Extended Healthspan

AI's Impact on Longevity and the Replication of Human Likeness

NAD's Value in Combating Fatigue and Long COVID

Part 5: Practical Applications and Conclusion

NAD as the Next Vitamin D and the Importance of Zinc, D, and Niagen

Skepticism Towards Creatine and the Importance of NAD

Closing Remarks and Resources for Further Learning

541: Can a Pill Help You Live Longer? The Science Behind NAD and Longevity | Robert Fried

The Genius Life

Part 1: Introduction to NAD and Cellular Health

00:19NAD: The Molecule Central to Cellular Energy, Mitochondrial Function, and DNA Repair

NAD: The Molecule Central to Cellular Energy, Mitochondrial Function, and DNA Repair

01:17NAD's Role in Energy Production, Mitochondrial Health, and Cellular Repair

NAD's Role in Energy Production, Mitochondrial Health, and Cellular Repair

05:11The Relationship Between Declining NAD Levels, Aging, and Cellular Performance

The Relationship Between Declining NAD Levels, Aging, and Cellular Performance

07:26NAD as an Aging Biomarker and its Impact on Healthspan

NAD as an Aging Biomarker and its Impact on Healthspan

Part 2: Scientific Research and the NR Pathway

10:13Animal and Human Studies on NAD and its Potential in Treating Diseases

Animal and Human Studies on NAD and its Potential in Treating Diseases

14:44NAD, NR, and the Discovery of the NR Kinase Pathway

NAD, NR, and the Discovery of the NR Kinase Pathway

21:18Expectations and Scientific Approach to TruNiagen Supplementation

Expectations and Scientific Approach to TruNiagen Supplementation

27:56Supplement Quality, Bioavailability, and the Problem of Misinformation

Supplement Quality, Bioavailability, and the Problem of Misinformation

Part 3: Origins, Background, and Longevity Strategy

33:36NR in Dairy and Robert Fried's Background

NR in Dairy and Robert Fried's Background

35:33Robert Fried's Journey into the Longevity Space and NAD Research

Robert Fried's Journey into the Longevity Space and NAD Research

43:16The Future of NAD Research in Pharma, Biotech, and Cosmetics

The Future of NAD Research in Pharma, Biotech, and Cosmetics

45:00NAD Supplementation, Cancer Risk, and Niacin

NAD Supplementation, Cancer Risk, and Niacin

Part 4: Future Outlook, AI, and Healthspan

49:06Erasing BS Narratives in Longevity and the Pursuit of Extended Healthspan

Erasing BS Narratives in Longevity and the Pursuit of Extended Healthspan

51:27AI's Impact on Longevity and the Replication of Human Likeness

AI's Impact on Longevity and the Replication of Human Likeness

55:03NAD's Value in Combating Fatigue and Long COVID

NAD's Value in Combating Fatigue and Long COVID

Part 5: Practical Applications and Conclusion

58:10NAD as the Next Vitamin D and the Importance of Zinc, D, and Niagen

NAD as the Next Vitamin D and the Importance of Zinc, D, and Niagen

1:00:30Skepticism Towards Creatine and the Importance of NAD

Skepticism Towards Creatine and the Importance of NAD

1:05:31Closing Remarks and Resources for Further Learning

Closing Remarks and Resources for Further Learning