Dr. Mindy Pelz returns to explore the deeper meaning of aging, menopause, and the profound psychological and neurological transformations women undergo as they grow older. Drawing from neuroscience, anthropology, mythology, and personal experience, Mindy reframes menopause not as a decline—but as an initiation into wisdom, sovereignty, and inner authority.

We discuss the concept of the “second innocence,” the pruning and rewiring of the female brain across hormonal transitions, the grandmother hypothesis, and why modern culture fears aging women. Mindy shares how trauma, grief, solitude, and uncertainty can become gateways to resilience, neuroplasticity, and self-discovery—especially when women stop outsourcing their worth and begin listening inward.

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Andrés Book Recs: https://www.knowthyselfpodcast.com/book-list

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00:00 Intro - Dr. Mindy Pelz

03:39 The return to the second innocence

08:18 What’s the purpose of menopause?

16:09 Where the shift begins

23:04 Supporting others without abandoning yourself

31:57 Being considerate vs owning others’ emotions

34:14 Ad: Pique Life

35:55 The power of solitude

43:26 Letting go

52:48 From power over to power within

56:48 The brain architecture of wisdom

1:02:24 Transformation: From a caterpillar to a butterfly

1:19:58 Fasting during menopause

1:26:35 Knowing when and how to detox

1:32:31 Healing through breathwork, EMDR, psilocybin

1:45:12 Lacking a support system

1:49:07 Closing thoughts

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Episode Resources:

Her new book: https://bookshop.org/p/books/age-like-a-girl-why-the-brain-changes-that-happen-after-40-set-you-up-for-your-best-life-yet-dr-mindy-pelz/1d7c0fe95ab52c4f?ean=9781401975562&next=t

https://www.instagram.com/dr.mindypelz

https://www.drmindypelz.com/

https://www.instagram.com/andreduqum/

https://www.instagram.com/knowthyself/

https://www.youtube.com/@knowthyselfpodcast

https://www.knowthyselfpodcast.com

E176 - Dr. Mindy Pelz: Why Midlife Feels So Disorienting (And What It’s Trying to Teach You)

Know Thyself