Acetylation Insights: Unlocking Longevity Secrets with Dr. Haim Cohen

In this episode of the Longevity by Design podcast, Dr. Gil Blander interviews Dr. Haim Cohen, a leading expert in aging biology, about his research on SIRT6 and the global effects of acetylation on longevity across different mammalian species. Dr. Cohen provides updates on his SIRT6 studies, including tissue-specific effects and its role in metabolic balance in the hypothalamus. The conversation then shifts to Dr. Cohen's Nature paper on acetylation, where he explains the experimental design, the platform built to analyze acetylation sites in 107 mammalian species, and the goal of identifying longevity-associated acetylation sites. They discuss the role of H2S, DNA repair pathways, and the Pitot Paradox in the context of acetylation and longevity, as well as potential therapeutic implications of the findings. Dr. Cohen concludes with his top longevity tip: aligning activity and diet cycles by avoiding late-night eating.