New Center for Pediatric CRISPR Cures

Eric Topol interviews Jennifer Doudna and Priscilla Chan about the new center for pediatric CRISPR cures. They discuss their backgrounds, how they started working together, and the Chan Zuckerberg Initiative's focus on basic science research and rare diseases. Doudna details the successful CRISPR cure of baby KJ, who had a rare metabolic disorder, highlighting the rapid timeline and innovative use of base editing and mRNA delivery. Chan shares her vision for the new center, emphasizing the importance of streamlining the treatment process, reducing costs, and expanding access to CRISPR therapies. Doudna explains how the IGI is partnering with Danaher to reduce the cost of manufacturing CRISPR therapies. They also discuss expanding the center's focus to include the bone marrow and immune system, with the goal of treating a wider range of diseases.