In this episode of The Dr. Hyman Show, Dr. Mark Hyman interviews Dr. Jeffrey Bland, the father of functional medicine, about optimizing health and longevity through understanding the body as a system. They discuss Dr. Bland's personal journey, the importance of mitochondrial and immune health, and the role of diet in regulating inflammation and gene expression. Dr. Bland emphasizes the significance of the immune system's communication with the outside world and introduces the concept of immunorejuvenation. The conversation explores the power of food, particularly phytochemicals, in modulating the immune system and preventing chronic diseases, highlighting the potential of personalized lifestyle medicine and the integration of digital tools for better health outcomes.