In "The Next Big Idea," Caleb Bissinger interviews Alex Hutchinson, author of "The Explorer's Gene," about the science and importance of exploration. Hutchinson defines exploration as making choices with uncertain outcomes, involving risk and potential failure, and argues it's a fundamental human drive, supported by anthropology, neuroscience, and biology. They discuss the "explore-exploit dilemma," the societal tendency to favor exploitation over exploration due to immediate feedback, and the neurological basis for novelty-seeking, including the DRD4 gene and predictive processing. Hutchinson advocates for balancing habits with exploration, fostering curiosity, and embracing the inherent meaningfulness and satisfaction derived from challenging oneself and pushing beyond the comfort zone, even in small, everyday ways. He suggests that a decline in exploration leads to less meaningful lives and stifles innovation.