In this episode, I’m joined by Dr. Melanie Cree—physician-scientist, pediatric endocrinologist, and one of the leading researchers redefining how we understand and treat Polycystic Ovary Syndrome (PCOS). PCOS affects millions of women, yet it's still underdiagnosed, misunderstood, and often mistreated. Dr. Cree cuts through the confusion, offering a deeply scientific yet compassionate look at what’s really driving this complex condition—from insulin resistance and mitochondrial dysfunction to skeletal muscle quality and fertility trajectories across a woman’s lifespan.

We cover:

Why PCOS isn’t a single disease—and what two phenotypes may explain the full picture
How muscle, liver, and fat interact in PCOS
The misunderstood role of testosterone, insulin, and SHBG in diagnosis
What muscle biopsies reveal about teenage girls with PCOS
Intramuscular fat, mitochondrial impairment, and the true cost of sedentary muscle
How early lifestyle and exercise interventions could change the future of PCOS care
What GLP-1 agonists and amino acid supplements might offer for treatment

Whether you’re a clinician, patient, or advocate for women’s health, this episode will give you a whole new lens on PCOS—and why skeletal muscle may be the most overlooked (and powerful) organ in the conversation.

Who is Dr. Melanie Cree?

Dr. Melanie Cree is a board-certified pediatric endocrinologist and Associate Professor at the University of Colorado and Children’s Hospital Colorado, where she directs a leading multidisciplinary PCOS clinic. Her research bridges metabolic medicine and muscle physiology, with clinical trials exploring semaglutide, amino acid therapy, liver metabolism, and insulin resistance in adolescents.

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Find Dr. Melanie Cree at:

University of Colorado - https://som.cuanschutz.edu/Profiles/Faculty/Profile/22449

Find me at:

Instagram: @drgabriellelyon
TikTok: @drgabriellelyon
Facebook: facebook.com/doctorgabriellelyon
YouTube:

GLP-1 & PCOS Breakthroughs: How Ozempic is Changing Women’s Health | Dr. Melanie Cree

The Dr. Gabrielle Lyon Show