This episode explores the challenges of scaling up successful research interventions into effective, large-scale policies. Against the backdrop of remarkable medical and technological advancements, the discussion highlights the frequent failure to translate promising research findings into real-world impact, citing examples like hypertension treatment and cochlear implant usage. More significantly, the conversation delves into the "scalability crisis," where interventions effective in small-scale trials falter when implemented broadly. For instance, a successful parent academy program in Chicago Heights failed miserably when attempted in London due to low parental participation. The hosts and guests analyze this failure through three key lenses: insufficient evidence, studying the wrong population, and unsuitable implementation contexts. They propose a solution involving rigorous replication of research findings before scaling, emphasizing the need for "implementation science" to bridge the gap between research and policy. Ultimately, this episode underscores the critical need for a more robust, replicable research process and a deeper understanding of human behavior to ensure that promising interventions translate into meaningful societal change.