This episode explores hormone optimization, focusing on the importance of understanding hormonal balance throughout the day rather than relying on single-point blood tests. Against the backdrop of a discussion about the hosts' own hormone tests, Dr. Cabral emphasizes the diurnal rhythm of hormones like cortisol, highlighting the detrimental effects of elevated evening cortisol on sleep and aging. More significantly, the conversation delves into the common imbalances observed in both men and women, such as estrogen dominance in women and declining DHEA and testosterone in men, often linked to chronic stress. For instance, Dr. Cabral explains how chronic stress depletes DHEA, a precursor hormone, ultimately leading to lower testosterone levels. The discussion then pivots to the role of DHEA supplementation in hormone replacement therapy and the concept of cortisol resistance. Finally, the episode concludes with a detailed analysis of the hosts' individual hormone test results, personalized recommendations for optimization, and a glimpse into the application of AI in analyzing large datasets of hormone test results to generate tailored protocols for patients.
