This episode explores the science behind protein, essential amino acids (EAAs), and creatine, examining their efficacy for muscle growth, fat loss, and longevity, and how needs change with age. Against the backdrop of a multi-billion dollar supplement industry, the discussion emphasizes evidence-based insights over marketing claims. The hosts delve into the hierarchy of protein sources, noting that beef is three times more potent in EAAs than plant-based sources like beans, while whey protein is even more concentrated than beef. More significantly, the conversation highlights the age-dependent effectiveness of EAAs, revealing that they are three times more effective than whey protein for stimulating protein synthesis in young adults, and this difference increases with age, becoming six times more effective for those in their 60s due to anabolic resistance. For instance, a 40-year-old could achieve the muscle protein synthesis equivalent of 20 grams of whey protein by consuming just 5 grams of EAAs. The discussion also addresses creatine's benefits, extending beyond muscle growth to include cognitive enhancement, particularly in situations of sleep deprivation or stress. Finally, the hosts tackle common misconceptions surrounding creatine, such as its potential for bloating or hair loss, and clarify that creatine monohydrate is the same regardless of gender, with dosage adjustments based on body weight rather than sex. What this means for consumers is a clearer understanding of the nuanced benefits and optimal usage of these supplements, emphasizing the importance of transparency in supplement labeling and the need for personalized approaches based on age and individual needs.