This "No Stupid Questions" episode explores the complex relationship between ambition, success, and selfishness, featuring a discussion between Stephen Dubner and Angela Duckworth. The conversation begins with a broad examination of self-interest versus selfishness, referencing Adam Smith's philosophy and the example of Jonas Salk's controversial but ultimately beneficial development of the polio vaccine. They delve into the concept of habituation, using the Holland Tunnel and everyday examples to illustrate how we become desensitized to remarkable things. Duckworth shares personal anecdotes about her upbringing and its influence on her views of selflessness. The discussion concludes with reflections on the importance of mindful appreciation for life's everyday marvels and the potential for integrating ambition with prosocial behavior. A key takeaway is the idea that sustainable giving requires considering both one's own well-being and the needs of others.