In this podcast episode, the focus is on the clinical significance of ApoB, a type of lipoprotein particle, in evaluating and managing cardiovascular disease risk. While LDL cholesterol is often the go-to measure, ApoB provides a more accurate count of atherogenic lipoprotein particles, helping to clarify residual risk even after LDL levels are reduced. The conversation explores the intricacies of atherosclerosis, highlighting how lipoprotein retention, ApoB levels, metabolic health, and imaging tests like coronary artery calcium scoring and carotid ultrasound all interact. Clinicians are urged to consider ApoB testing, especially when LDL cholesterol results are inconsistent, to enhance treatment strategies and improve patient outcomes.