This podcast explores the best structures for Amazon PPC campaigns focused on sponsored products. It compares three key approaches: multi-product ad groups, ideal for large catalogs with limited data on individual items; single-product ad groups, which work well for extensive catalogs with good data on specific products; and single-product campaigns, which are recommended for sellers with fewer than 500 SKUs and adequate product data. The discussion also emphasizes the importance of launching multiple campaigns for each product, targeting both research and performance. Advanced users might consider single-keyword campaigns for their top keywords, but the podcast warns against using this strategy for all keywords due to potential data dilution.