#207 - AMA #35: "Anti-Aging" Drugs — NAD+, metformin, & rapamycin | The Peter Attia Drive

This is a sneak peek of an Ask Me Anything (AMA) episode of The Drive Podcast, hosted by Peter Attia, featuring Nick Stenson and Matt Kaeberlein. The episode focuses on the science of aging, specifically discussing three geroprotective molecules: NAD (and its precursors NR and NMN), rapamycin, and metformin. The discussion begins with an overview of aging biomarkers, their limitations, and the challenges in accurately measuring biological age. The speakers delve into epigenetic clocks, their potential, and the existing gaps in research, particularly the lack of definitive lifespan studies in mice. They also explore the complexities of interpreting aging studies across different models (yeast, worms, flies, mice, dogs, and humans) and the importance of functional biomarkers in assessing the effectiveness of interventions aimed at improving healthspan and lifespan.

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#207 - AMA #35: "Anti-Aging" Drugs — NAD+, metformin, & rapamycin

The Peter Attia Drive

Introduction to Ask Me Anything Episode 35: Aging and Geroprotective Molecules

Focus on NAD, Rapamycin, and Metformin for Aging Research

Accessing the Full Episode and the Rationale for Including Rapamycin and Metformin

Three-Person AMA and the Importance of Comparing Geroprotective Molecules

Introduction to Biomarkers of Aging

Defining and Assessing Biomarkers of Biological Aging

The Importance of Biomarkers Reflecting Rate of Aging and Intervention Response

Reversal vs. Slowing of Aging and the Importance of Functional Biomarkers

Clinical Practice and the Use of Functional and Phenotypic Markers

Epigenetic Clocks: How They Work and What They Measure

Evidence and Limitations of Epigenetic Clocks

The Need for Definitive Lifespan Studies in Mice and Different Types of Epigenetic Clocks

Broad Aging Clocks vs. Methylation-Specific Clocks and the Importance of Individual-Level Prediction

The Potential for Existing Biomarkers and the Need for Precision

Concerns About Commercialization and "Moving the Goalpost"

The Dishonesty of Selling Aging Clocks and Products That Claim to Reverse Biological Age

Outro

#207 - AMA #35: "Anti-Aging" Drugs — NAD+, metformin, & rapamycin

The Peter Attia Drive

00:10Introduction to Ask Me Anything Episode 35: Aging and Geroprotective Molecules

Introduction to Ask Me Anything Episode 35: Aging and Geroprotective Molecules

01:23Focus on NAD, Rapamycin, and Metformin for Aging Research

Focus on NAD, Rapamycin, and Metformin for Aging Research

03:32Accessing the Full Episode and the Rationale for Including Rapamycin and Metformin

Accessing the Full Episode and the Rationale for Including Rapamycin and Metformin

05:20Three-Person AMA and the Importance of Comparing Geroprotective Molecules

Three-Person AMA and the Importance of Comparing Geroprotective Molecules

07:09Introduction to Biomarkers of Aging

Introduction to Biomarkers of Aging

08:40Defining and Assessing Biomarkers of Biological Aging

Defining and Assessing Biomarkers of Biological Aging

10:31The Importance of Biomarkers Reflecting Rate of Aging and Intervention Response

The Importance of Biomarkers Reflecting Rate of Aging and Intervention Response

12:31Reversal vs. Slowing of Aging and the Importance of Functional Biomarkers

Reversal vs. Slowing of Aging and the Importance of Functional Biomarkers

14:10Clinical Practice and the Use of Functional and Phenotypic Markers

Clinical Practice and the Use of Functional and Phenotypic Markers

15:23Epigenetic Clocks: How They Work and What They Measure

Epigenetic Clocks: How They Work and What They Measure

17:14Evidence and Limitations of Epigenetic Clocks

Evidence and Limitations of Epigenetic Clocks

19:14The Need for Definitive Lifespan Studies in Mice and Different Types of Epigenetic Clocks

The Need for Definitive Lifespan Studies in Mice and Different Types of Epigenetic Clocks

20:36Broad Aging Clocks vs. Methylation-Specific Clocks and the Importance of Individual-Level Prediction

Broad Aging Clocks vs. Methylation-Specific Clocks and the Importance of Individual-Level Prediction

22:21The Potential for Existing Biomarkers and the Need for Precision

The Potential for Existing Biomarkers and the Need for Precision

23:43Concerns About Commercialization and "Moving the Goalpost"

Concerns About Commercialization and "Moving the Goalpost"

26:48The Dishonesty of Selling Aging Clocks and Products That Claim to Reverse Biological Age

The Dishonesty of Selling Aging Clocks and Products That Claim to Reverse Biological Age

27:35Outro

Outro