This podcast episode details the innovative journey taken by Cesar de la Fuente and his team in combating the escalating threat of antibiotic resistance through a combination of artificial intelligence and ancient biology. By harnessing cutting-edge technologies to explore both the human proteome and the vast extinctome, they have uncovered thousands of new antibiotic candidates, particularly focusing on ancient organisms and their unique molecules. This groundbreaking work not only reveals the untapped potential of AI in rapid antibiotic discovery but also emphasizes the significance of preserving and studying evolutionary history to address contemporary health crises.