22 Jul 2024

#310 - The relationship between testosterone and prostate cancer, testosterone replacement therapy, and tools for predicting cancer aggressiveness and guiding therapy | Ted Schaeffer, M.D., Ph.D.

The Peter Attia Drive

This podcast episode explores the role of testosterone in prostate cancer and the implications for testosterone replacement therapy. The discussion focuses on the findings of the TRAVERSE trial, which examined the use of exogenous testosterone and its impact on cardiovascular disease. The experts emphasize the importance of evidence-based information and debunk misinformation in considering testosterone replacement therapy. The episode also delves into the saturation theory and its implications for the androgen receptor in different end organs. The correlation between testosterone levels and the risk of high-grade prostate cancer is discussed, along with the characteristics of aggressive tumors and the use of gene expression analysis. The ARA score and the Decipher score are highlighted as valuable tools in treatment decision-making for prostate cancer. Furthermore, the conversation addresses the use of testosterone replacement therapy and the considerations for patients with prostate cancer. Differentiation points in prostate cancer treatment and the progress made in patient care are also explored. The episode concludes with a brief mention of the differences in treatments for prostate and breast cancer and the reliance on member support for ad-free content.

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