Peter Attia, MD · Health

The Peter Attia Drive

Expert insight on health, performance, longevity, critical thinking, and pursuing excellence. Dr. Peter Attia (Stanford/Hopkins/NIH-trained MD) talks with leaders in their fields.

Episodes

#391 ‒ Colorectal cancer screening: importance of early screening, colonoscopy as a screening and preventive tool, and how to build a personalized strategy

11 May 2026

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Colorectal cancer (CRC) is the second leading cause of cancer mortality in the United States, yet it remains the most preventable malignancy due to its slow, decade-long progression from benign polyps to malignancy. Unlike screening tools for breast or lung cancer, a colonoscopy provides the unique dual benefit of dire...

#390 ‒ AMA #84: Family health history, preventing heart disease, metabolic health, strength training efficiency, dementia risk reduction, NAD supplements, and hydration

04 May 2026

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Family health history serves as a more potent diagnostic tool than genetic testing for most chronic conditions because diseases like heart disease, cancer, and diabetes typically arise from a polygenic backdrop rather than single-gene mutations. While genetic testing offers clarity for specific conditions with complete...

#389 - Thinking scientifically: why it's hard, why it matters, and a practical toolkit

27 Apr 2026

53m

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Scientific thinking functions as a disciplined process for navigating uncertainty and making better decisions by prioritizing the methodology behind a claim over the conclusion itself. Because human cognition is evolutionarily optimized for social belonging rather than objective truth, individuals must rely on "prosthe...

#388 — Prostate cancer screening: why current PSA guidelines are failing men and how modern tools improve early detection and save lives

20 Apr 2026

46m

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Prostate cancer screening requires a modern, nuanced approach to reverse the rising incidence of metastatic disease caused by outdated, overly cautious guidelines. While the United States Preventive Services Task Force previously discouraged routine PSA testing due to concerns over overtreatment and biopsy-related comp...

#387 - AMA #83: Peptides—evaluating the science, safety, and hype in a rapidly growing field

13 Apr 2026

22m

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Peptides function as short chains of amino acids that serve critical biological roles as signaling molecules and hormones, yet their current popularity in the biohacking and longevity communities often outpaces scientific consensus. Evaluating these compounds requires a rigorous framework that assesses the existence of...

#386 - Aging clocks—what they measure, how they work, and their clinical and real-world relevance

06 Apr 2026

55m

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The podcast explores the utility of aging clocks, which aim to predict biological age and rate of aging, as opposed to chronological age. It highlights the potential of aging clocks to compress the multidimensional aspects of aging into a single number, offering speed and individual feedback for clinical trials and per...

#385 - AMA #82: Applying the tools of longevity in the real world: disease prevention, DEXA scans, artificial sweeteners, injury recovery, stability training, habit formation, protein intake and mTOR activation, and more

23 Mar 2026

18m

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This AMA episode addresses listener questions on shifting health priorities across different life stages, from the flexibility of the 20s to the maintenance and potential for growth in the 60s and beyond. It emphasizes metabolic health and consistent exercise as key factors, especially in the 40s, while cautioning agai...

#384 - Special episode — Obicetrapib: The CETP inhibitor with cardiovascular benefits and potential Alzheimer's prevention

16 Mar 2026

52m

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Obicetrapib, a CETP inhibitor, is examined for its potential in reducing LDL cholesterol and its possible implications for Alzheimer's disease, particularly in individuals carrying the APOE4 allele. The history of CETP inhibitors, including failed drugs like torcetrapib and dalcetrapib, is revisited, emphasizing how ob...

#381 ‒ Alzheimer's disease in women: how hormonal transitions impact the female brain, the role of HRT, genetics, and lifestyle on risk, and emerging diagnostics and therapies | Lisa Mosconi, Ph.D.

26 Jan 2026

2h 6m

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This podcast explores the disproportionate impact of Alzheimer's disease on women, challenging the assumption that increased longevity is the sole factor. Neuroscientist Lisa Mosconi discusses her personal connection to the topic and her research on how menopause and hormonal transitions shape brain aging and Alzheimer...

#380 ‒ The seed oil debate: are they uniquely harmful relative to other dietary fats? | Layne Norton, Ph.D.

19 Jan 2026

2h 7m

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The podcast explores the controversy surrounding seed oils and their potential harm, dissecting arguments against their consumption. It addresses the mortality literature from large RCTs, particularly those substituting saturated fats with polyunsaturated fats, and examines the role of trans fats as confounders in olde...

#379 - AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence

12 Jan 2026

38m

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This podcast episode focuses on cardiorespiratory fitness, specifically zone 2 and VO2 max, as key modifiable predictors of healthspan and lifespan. It addresses how to measure, track, and improve these metrics through training, considering time constraints, training experience, and age. The discussion clarifies the ro...

#378 ‒ Women's health and performance: how training, nutrition, and hormones interact across life stages | Abbie Smith-Ryan, Ph.D.

05 Jan 2026

2h 11m

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The podcast explores exercise and nutrition strategies tailored to women's health across their lifespan. Abbie Smith-Ryan, an expert in exercise physiology, discusses topics ranging from bone health in young girls to managing training and nutrition through the menstrual cycle, perimenopause, and menopause. Early exerci...

Building & Changing Habits | James Clear (#183 rebroadcast)

29 Dec 2025

2h 19m

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In this special New Year's episode of The Drive podcast, Peter Attia re-releases his discussion with James Clear, author of "Atomic Habits," focusing on the science of habit formation and behavior change. They delve into the evolutionary rationale for habits, the challenges of changing them in modern society, and the i...

#377 ‒ Special episode: Understanding true happiness and the tools to cultivate a meaningful life—insights from past interviews with Arthur Brooks

22 Dec 2025

1h 39m

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In this episode of The Drive Podcast, host Peter Attia presents a "Best of" compilation featuring Arthur Brooks, a Harvard professor and social scientist. The episode focuses on building a life that balances success and happiness, exploring themes such as understanding happiness versus happy feelings, identifying facto...

#376 - AMA #78: Longevity interventions, exercise, diagnostic screening, and managing high apoB, hypertension, metabolic health, and more

15 Dec 2025

22m

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This is a sneak peek of an Ask Me Anything (AMA) episode of The Drive Podcast with Peter Attia, focusing on listener questions about lifespan interventions, cardiovascular risk, fasting, blood pressure management, hormone replacement therapy, and diagnostic screening. Peter discusses his personal, clinical, and philoso...

#375 - Ketogenic diet, ketosis & hyperbaric oxygen: metabolic therapies for weight loss, cognition, Alzheimer's & more | Dom D'Agostino, Ph.D.

08 Dec 2025

2h 8m

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In this episode of The Drive, Peter Attia interviews Dom D'Agostino, a neuroscientist and professor, about metabolic therapies, including ketogenic diets, exogenous ketones, and hyperbaric oxygen. They discuss the differences between nutritional and supplemental ketosis, how to achieve clinical ketosis while maintainin...

#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

01 Dec 2025

2h 5m

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In this episode of The Drive, Peter Attia interviews Carole Hooven, a human evolutionary biologist, about the role of testosterone and other sex hormones in shaping sex differences in humans and other mammals. They discuss prenatal testosterone exposure and its effects on the development of the body and brain, the evol...

The impact of gratitude, serving others, embracing mortality, and living intentionally | Walter Green (#288 rebroadcast)

24 Nov 2025

1h 31m

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In this special Thanksgiving episode of The Drive podcast, Peter Attia rebroadcasts his conversation with Walter Green, a philanthropist, mentor, and author, focusing on gratitude, service, and intentional living. They discuss Walter's life journey, shaped by early challenges and a near-death experience at 53, which in...

#373 – Thyroid function and hypothyroidism: why current diagnosis and treatment fall short for many, and how new approaches are transforming care | Antonio Bianco, M.D., Ph.D.

17 Nov 2025

2h 20m

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In this episode of The Drive podcast, Peter Attia interviews Dr. Antonio Bianco, an expert in thyroid physiology and metabolism, about the biology of thyroid hormone production, conversion, and action. They discuss how diodinase enzymes regulate thyroid hormone activity, the limitations of using TSH as a marker, combin...

#372 - AMA #77: Dietary fiber and health outcomes: real benefits, overhyped claims, and practical applications

10 Nov 2025

24m

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This is a sneak peek of Peter Attia's "Ask Me Anything" (AMA) podcast, specifically episode 77, which delves into the science of dietary fiber. The episode aims to move beyond generic advice and explore the actual effects of different types of fiber (soluble, insoluble, viscous, and fermentable) on the body, their impa...

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