The Peter Attia Drive

#244 ‒ The history of the cell, cell therapy, gene therapy, and more | Siddhartha Mukherjee

This podcast episode explores the complex and fascinating world of cell biology, gene therapy, and gene editing. Through interviews with experts in the field and personal anecdotes, this episode sheds light on the historical evolution of biomedical research and the potential of these technologies to transform modern me...

#243 ‒ The fentanyl crisis and why everyone should be paying attention | Anthony Hipolito

This podcast episode discusses the rising prevalence and dangers of fentanyl, a synthetic opioid more potent than morphine. It explores how fentanyl has become a major contributor to accidental overdoses, particularly among young people, revealing the tactics employed by drug cartels to target this vulnerable demograph...

#242 - AMA #44: Peter's historical changes in body composition with his evolving dietary, fasting, and training protocols

This podcast episode discusses Peter Attia's 12-year body composition journey, using DEXA scans to track his progress. The episode emphasizes the importance of assessing body composition beyond a single scan, considering factors like visceral fat, bone mineral density, muscle mass, and inflammatory markers. The episode...

#241 ‒ Living intentionally, valuing time, prioritizing relationships, and more keys to a rich life | Ric Elias (Part 2)

This podcast episode delves into the evolving nature of parenting, friendships, purpose, and the pursuit of a meaningful life. It emphasizes the importance of adapting to changing relationships, embracing new experiences, and recognizing that one's age is not defined by physical abilities but by their mindset and outlo...

#240 ‒ The confusion around HDL and its link to cardiovascular disease | Dan Rader, M.D.

This podcast episode explores the complex nature of HDL (high-density lipoprotein), its role in cardiovascular health, and its potential implications for neurodegenerative diseases. It delves into the molecular biology of HDL, its structural differences with LDL (low-density lipoprotein), and the challenges of pharmaco...

#239 ‒ The science of strength, muscle, and training for longevity | Andy Galpin, Ph.D. (PART I)

This podcast episode explores the intricacies of strength training and its profound impact on longevity. It emphasizes the role of muscle mass in protecting against age-related muscle loss and discusses various types of strength training exercises tailored to different goals. The podcast also delves into the physiologi...

#238 – AMA #43: Understanding apoB, LDL-C, Lp(a), and insulin as risk factors for cardiovascular disease

This podcast episode delves into the multifaceted nature of atherosclerotic cardiovascular disease (ASCVD) risk factors and their collective influence on cardiovascular health. The speakers discuss various factors, including apolipoprotein B (apoB), lipoprotein(a) (LpLA), and insulin, and how they impact ASCVD risk. Th...

#237 ‒ Optimizing life for maximum fulfillment | Bill Perkins

This podcast episode delves into the complexities of life optimization by exploring the interconnectedness of wealth, health, and experiences. It emphasizes the importance of prioritizing time and fulfillment over mere wealth accumulation, encouraging listeners to intentionally design their lives and make conscious cho...

#236 ‒ Neurodegenerative disease: pathology, screening, and prevention | Kellyann Niotis, M.D.

This podcast episode explores the multifaceted world of neurodegenerative diseases, delving into their causes, risk factors, and potential interventions. It highlights the link between oral health, exercise, and reduced risk of Alzheimer's disease, emphasizing the significance of preventive strategies. The discussion u...

James Clear: Building & Changing Habits (#183 rebroadcast)

#235 ‒ Training principles for mass and strength, changing views on nutrition, creatine supplementation, and more | Layne Norton, Ph.D.

Layne Norton, a bodybuilding and physique coach, joins Peter Attia to discuss powerlifting, strength training, nutrition, and fitness industry trends. The conversation explores how non-powerlifters can apply powerlifting principles to improve overall strength and longevity, emphasizing progressive overload through weig...

#234 ‒ Chris Hemsworth on Limitless, longevity, and happiness

#233 - AMA #42: Optimizing sleep - bedtime routine, molecule regimen, sleep trackers, sauna, & more

Sleep optimization relies on consistent behavioral practices rather than rigid protocols. Avoiding alcohol and maintaining a three-hour gap between the final meal and bedtime significantly enhance sleep quality. Sauna use serves as a powerful tool for both physiological recovery and sleep induction, though its implemen...

#232 ‒ Shoulder, elbow, wrist, and hand: diagnosis, treatment, and surgery of the upper extremities | Alton Barron, M.D.

The upper extremity’s evolutionary shift toward mobility over stability necessitates a nuanced approach to orthopedic care, where clinical examination often outweighs imaging in diagnostic accuracy. Shoulder pathology, ranging from labral tears to rotator cuff injuries, requires careful consideration of biological age ...

A masterclass on insulin resistance—mechanisms and implications | Gerald Shulman, M.D., Ph.D. (#140 rebroadcast)

This episode explores the complexities of insulin resistance, a prevalent metabolic condition underlying many chronic diseases. The conversation begins by establishing insulin resistance as a primary driver of type 2 diabetes, but also a significant contributor to cardiovascular disease, fatty liver disease, and vario...

#231 - AMA #41: Medicine 3.0, developments in the field of aging, healthy habits in times of stress, and more

#230 ‒ Cardiovascular disease in women: prevention, risk factors, lipids, and more | Erin Michos, M.D.

#229 ‒ Understanding cardiovascular disease risk, cholesterol, and apoB

Atherosclerotic cardiovascular disease (ASCVD) represents a ubiquitous, inevitable condition that requires proactive, early-life intervention rather than reliance on traditional 10-year risk calculators. Cholesterol is an essential molecule for cellular function and hormone production, yet its clinical assessment is of...

#228 ‒ Improving body composition, female-specific training principles, and overcoming an eating disorder | Holly Baxter, APD

In this episode of The Drive Podcast, Peter Attia interviews Holly Baxter, a dietician, bodybuilder, and physique coach, about her background, her interest in nutrition, and her past struggles with an eating disorder. Holly shares her personal experiences with anorexia, bulimia, and binge eating disorder, discussing th...

#227 - AMA #40: Body composition, protein, time-restricted feeding, fasting, DEXA scans, and more